| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 1980 | W | New York Giants | @ | St. Louis Cardinals | 41 | 35 | box |
| 2 | Sun | September 14, 1980 | L | New York Giants | Washington Redskins | 21 | 23 | box | |
| 3 | Mon | September 22, 1980 | L | New York Giants | @ | Philadelphia Eagles | 3 | 35 | box |
| 4 | Sun | September 28, 1980 | L | New York Giants | Los Angeles Rams | 7 | 28 | box | |
| 5 | Sun | October 5, 1980 | L | New York Giants | @ | Dallas Cowboys | 3 | 24 | box |
| 6 | Sun | October 12, 1980 | L | New York Giants | Philadelphia Eagles | 16 | 31 | box | |
| 7 | Sun | October 19, 1980 | L | New York Giants | @ | San Diego Chargers | 7 | 44 | box |
| 8 | Sun | October 26, 1980 | L | New York Giants | Denver Broncos | 9 | 14 | box | |
| 9 | Sun | November 2, 1980 | L | New York Giants | @ | Tampa Bay Buccaneers | 13 | 30 | box |
| 10 | Sun | November 9, 1980 | W | New York Giants | Dallas Cowboys | 38 | 35 | box | |
| 11 | Sun | November 16, 1980 | W | New York Giants | Green Bay Packers | 27 | 21 | box | |
| 12 | Sun | November 23, 1980 | L | New York Giants | @ | San Francisco 49ers | 0 | 12 | box |
| 13 | Sun | November 30, 1980 | L | New York Giants | St. Louis Cardinals | 7 | 23 | box |