| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Mon | September 5, 1988 | W | New York Giants | Washington Redskins | 27 | 20 | box | |
| 2 | Sun | September 11, 1988 | L | New York Giants | San Francisco 49ers | 17 | 20 | box | |
| 3 | Sun | September 18, 1988 | W | New York Giants | @ | Dallas Cowboys | 12 | 10 | box |
| 4 | Sun | September 25, 1988 | L | New York Giants | Los Angeles Rams | 31 | 45 | box | |
| 5 | Sun | October 2, 1988 | W | New York Giants | @ | Washington Redskins | 24 | 23 | box |
| 6 | Mon | October 10, 1988 | L | New York Giants | @ | Philadelphia Eagles | 13 | 24 | box |
| 7 | Sun | October 16, 1988 | W | New York Giants | Detroit Lions | 30 | 10 | box | |
| 8 | Sun | October 23, 1988 | W | New York Giants | @ | Atlanta Falcons | 23 | 16 | box |
| 9 | Sun | October 30, 1988 | W | New York Giants | @ | Detroit Lions | 13 | 10 | box |
| 10 | Sun | November 6, 1988 | W | New York Giants | Dallas Cowboys | 29 | 21 | box | |
| 11 | Sun | November 13, 1988 | L | New York Giants | @ | Phoenix Cardinals | 17 | 24 | box |
| 12 | Sun | November 20, 1988 | L | New York Giants | Philadelphia Eagles | 17 | 23 | box | |
| 13 | Sun | December 4, 1988 | W | New York Giants | Phoenix Cardinals | 44 | 7 | box | |
| 14 | Sun | December 11, 1988 | W | New York Giants | Kansas City Chiefs | 28 | 12 | box | |
| 15 | Sun | December 18, 1988 | L | New York Giants | @ | New York Jets | 21 | 27 | box |