| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 12, 1999 | W | St. Louis Rams | Baltimore Ravens | 27 | 10 | box | |
| 2 | Sun | September 26, 1999 | W | St. Louis Rams | Atlanta Falcons | 35 | 7 | box | |
| 3 | Sun | October 3, 1999 | W | St. Louis Rams | @ | Cincinnati Bengals | 38 | 10 | box |
| 4 | Sun | October 10, 1999 | W | St. Louis Rams | San Francisco 49ers | 42 | 20 | box | |
| 5 | Sun | October 17, 1999 | W | St. Louis Rams | @ | Atlanta Falcons | 41 | 13 | box |
| 6 | Sun | October 24, 1999 | W | St. Louis Rams | Cleveland Browns | 34 | 3 | box | |
| 7 | Sun | October 31, 1999 | L | St. Louis Rams | @ | Tennessee Titans | 21 | 24 | box |
| 8 | Sun | November 7, 1999 | L | St. Louis Rams | @ | Detroit Lions | 27 | 31 | box |
| 9 | Sun | November 14, 1999 | W | St. Louis Rams | Carolina Panthers | 35 | 10 | box | |
| 10 | Sun | November 21, 1999 | W | St. Louis Rams | @ | San Francisco 49ers | 23 | 7 | box |
| 11 | Sun | November 28, 1999 | W | St. Louis Rams | New Orleans Saints | 43 | 12 | box | |
| 12 | Sun | December 5, 1999 | W | St. Louis Rams | @ | Carolina Panthers | 34 | 21 | box |
| 13 | Sun | December 12, 1999 | W | St. Louis Rams | @ | New Orleans Saints | 30 | 14 | box |
| 14 | Sun | December 19, 1999 | W | St. Louis Rams | New York Giants | 31 | 10 | box | |
| 15 | Sun | December 26, 1999 | W | St. Louis Rams | Chicago Bears | 34 | 12 | box | |
| 16 | Sun | January 2, 2000 | L | St. Louis Rams | @ | Philadelphia Eagles | 31 | 38 | box |
| 17 | Sun | January 16, 2000 | W | St. Louis Rams | Minnesota Vikings | 49 | 37 | box | |
| 18 | Sun | January 23, 2000 | W | St. Louis Rams | Tampa Bay Buccaneers | 11 | 6 | box | |
| 19 | Sun | January 30, 2000 | W | St. Louis Rams | N | Tennessee Titans | 23 | 16 | box |