| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 2008 | W | Arizona Cardinals | @ | San Francisco 49ers | 23 | 13 | box |
| 2 | Sun | September 14, 2008 | W | Arizona Cardinals | Miami Dolphins | 31 | 10 | box | |
| 3 | Sun | September 21, 2008 | L | Arizona Cardinals | @ | Washington Redskins | 17 | 24 | box |
| 4 | Sun | September 28, 2008 | L | Arizona Cardinals | @ | New York Jets | 35 | 56 | box |
| 5 | Sun | October 5, 2008 | W | Arizona Cardinals | Buffalo Bills | 41 | 17 | box | |
| 6 | Sun | October 12, 2008 | W | Arizona Cardinals | Dallas Cowboys | 30 | 24 | box | |
| 7 | Sun | October 26, 2008 | L | Arizona Cardinals | @ | Carolina Panthers | 23 | 27 | box |
| 8 | Sun | November 2, 2008 | W | Arizona Cardinals | @ | St. Louis Rams | 34 | 13 | box |
| 9 | Mon | November 10, 2008 | W | Arizona Cardinals | San Francisco 49ers | 29 | 24 | box | |
| 10 | Sun | November 16, 2008 | W | Arizona Cardinals | @ | Seattle Seahawks | 26 | 20 | box |
| 11 | Sun | November 23, 2008 | L | Arizona Cardinals | New York Giants | 29 | 37 | box | |
| 12 | Thu | November 27, 2008 | L | Arizona Cardinals | @ | Philadelphia Eagles | 20 | 48 | box |
| 13 | Sun | December 7, 2008 | W | Arizona Cardinals | St. Louis Rams | 34 | 10 | box | |
| 14 | Sun | December 14, 2008 | L | Arizona Cardinals | Minnesota Vikings | 14 | 35 | box | |
| 15 | Sun | December 21, 2008 | L | Arizona Cardinals | @ | New England Patriots | 7 | 47 | box |
| 16 | Sun | December 28, 2008 | W | Arizona Cardinals | Seattle Seahawks | 34 | 21 | box | |
| 17 | Sat | January 3, 2009 | W | Arizona Cardinals | Atlanta Falcons | 30 | 24 | box | |
| 18 | Sat | January 10, 2009 | W | Arizona Cardinals | @ | Carolina Panthers | 33 | 13 | box |
| 19 | Sun | January 18, 2009 | W | Arizona Cardinals | Philadelphia Eagles | 32 | 25 | box | |
| 20 | Sun | February 1, 2009 | L | Arizona Cardinals | N | Pittsburgh Steelers | 23 | 27 | box |