| Rank | Player (age), + - HOFer, Bold - Active | Y/G | Years | Teams |
|---|---|---|---|---|
| 1. | Adrian Peterson (24) | 103.0 | 2007-2009 | min |
| 2. | LaDainian Tomlinson (30) | 90.6 | 2001-2009 | sdg |
| 3. | Clinton Portis (28) | 89.8 | 2002-2009 | 2TM |
| 4. | Edgerrin James (31) | 82.7 | 1999-2009 | 3TM |
| 5. | Larry Johnson (30) | 82.1 | 2003-2009 | 2TM |
| 6. | Jamal Lewis (30) | 81.3 | 2000-2009 | 2TM |
| 7. | Fred Taylor (33) | 79.7 | 1998-2009 | 2TM |
| 8. | Steven Jackson (26) | 79.6 | 2004-2009 | ram |
| 9. | Ricky Williams (32) | 77.5 | 1999-2009 | 2TM |
| 10. | Frank Gore (26) | 75.6 | 2005-2009 | sfo |
| 11. | Willie Parker (29) | 73.0 | 2004-2009 | pit |
| 12. | Ryan Grant (27) | 71.5 | 2007-2009 | gnb |
| 13. | Marshawn Lynch (23) | 70.7 | 2007-2009 | buf |
| 14. | Ronnie Brown (28) | 68.0 | 2005-2009 | mia |
| 15. | DeAngelo Williams (26) | 67.5 | 2006-2009 | car |
| 16. | Willis McGahee (28) | 66.8 | 2004-2009 | 2TM |
| 17. | Ahman Green (32) | 63.6 | 1998-2009 | 3TM |
| 18. | Thomas Jones (31) | 61.0 | 2000-2009 | 4TM |
| 19. | Maurice Jones-Drew (24) | 60.6 | 2006-2009 | jax |
| 20. | Joseph Addai (26) | 60.3 | 2006-2009 | clt |
| Cadillac Williams (27) | 60.3 | 2005-2009 | tam | |
| 22. | Julius Jones (28) | 59.4 | 2004-2009 | 2TM |
| 23. | Cedric Benson (27) | 57.1 | 2005-2009 | 2TM |
| 24. | Brian Westbrook (30) | 56.6 | 2002-2009 | phi |
| 25. | Laurence Maroney (24) | 52.6 | 2006-2009 | nwe |
| 26. | Marion Barber (26) | 51.8 | 2005-2009 | dal |
| 27. | Brandon Jacobs (27) | 50.6 | 2005-2009 | nyg |
| 28. | Michael Vick (29) | 48.0 | 2001-2009 | 2TM |
| 29. | Chris Brown (28) | 47.5 | 2003-2009 | 2TM |
| 30. | Michael Turner (27) | 45.1 | 2004-2009 | 2TM |
| 31. | LenDale White (25) | 43.2 | 2006-2009 | oti |
| 32. | Fred Jackson (28) | 41.3 | 2007-2009 | buf |
| 33. | Pierre Thomas (25) | 39.1 | 2007-2009 | nor |
| 34. | Reggie Bush (24) | 38.9 | 2006-2009 | nor |
| 35. | Michael Bennett (31) | 37.8 | 2001-2009 | 4TM |
| 36. | Jerious Norwood (26) | 37.0 | 2006-2009 | atl |
| 37. | Justin Fargas (29) | 36.6 | 2003-2009 | rai |
| 38. | Chester Taylor (30) | 36.2 | 2002-2009 | 2TM |
| 39. | LaMont Jordan (31) | 33.4 | 2001-2009 | 4TM |
| 40. | Derrick Ward (29) | 33.3 | 2004-2009 | 2TM |
| 41. | Leon Washington (27) | 32.4 | 2006-2009 | nyj |
| 42. | Ladell Betts (30) | 31.1 | 2002-2009 | was |
| 43. | Correll Buckhalter (31) | 30.7 | 2001-2009 | 2TM |
| 44. | Ahmad Bradshaw (23) | 29.4 | 2007-2009 | nyg |
| 45. | Samkon Gado (27) | 28.6 | 2005-2009 | 4TM |
| 46. | Vince Young (26) | 27.7 | 2006-2009 | oti |
| 47. | Daunte Culpepper (32) | 26.1 | 1999-2009 | 4TM |
| 48. | Maurice Morris (30) | 25.4 | 2002-2009 | 2TM |
| 49. | Le'Ron McClain (25) | 25.2 | 2007-2009 | rav |
| 50. | Mewelde Moore (27) | 25.1 | 2004-2009 | 2TM |