| Rank | Player (age), + - HOFer, Bold - Active | Y/G | Years | Teams |
|---|---|---|---|---|
| 1. | Adrian Peterson (24) | 97.5 | 2007-2009 | min |
| 2. | Clinton Portis (28) | 89.8 | 2002-2009 | 2TM |
| 3. | LaDainian Tomlinson (30) | 88.6 | 2001-2009 | sdg |
| 4. | Edgerrin James (31) | 82.7 | 1999-2009 | 3TM |
| 5. | Jamal Lewis (30) | 81.0 | 2000-2009 | 2TM |
| 6. | Steven Jackson (26) | 79.8 | 2004-2009 | ram |
| 7. | Fred Taylor (33) | 79.0 | 1998-2009 | 2TM |
| 8. | Ricky Williams (32) | 77.3 | 1999-2009 | 2TM |
| 9. | Frank Gore (26) | 76.2 | 2005-2009 | sfo |
| 10. | Larry Johnson (30) | 75.6 | 2003-2009 | 2TM |
| 11. | Ryan Grant (27) | 72.6 | 2007-2009 | gnb |
| 12. | Willie Parker (29) | 68.9 | 2004-2009 | pit |
| 13. | Ronnie Brown (28) | 68.0 | 2005-2009 | mia |
| 14. | Matt Forte (24) | 67.7 | 2008-2009 | chi |
| 15. | DeAngelo Williams (26) | 66.4 | 2006-2009 | car |
| 16. | Willis McGahee (28) | 65.0 | 2004-2009 | 2TM |
| 17. | Marshawn Lynch (23) | 63.4 | 2007-2009 | buf |
| 18. | Ahman Green (32) | 62.6 | 1998-2009 | 3TM |
| 19. | Maurice Jones-Drew (24) | 62.3 | 2006-2009 | jax |
| Thomas Jones (31) | 62.3 | 2000-2009 | 4TM | |
| 21. | Jonathan Stewart (22) | 61.5 | 2008-2009 | car |
| 22. | Joseph Addai (26) | 60.8 | 2006-2009 | clt |
| 23. | Cadillac Williams (27) | 60.0 | 2005-2009 | tam |
| 24. | Cedric Benson (27) | 59.9 | 2005-2009 | 2TM |
| 25. | Julius Jones (28) | 59.1 | 2004-2009 | 2TM |
| 26. | Brian Westbrook (30) | 56.0 | 2002-2009 | phi |
| 27. | Laurence Maroney (24) | 54.0 | 2006-2009 | nwe |
| 28. | Marion Barber (26) | 53.1 | 2005-2009 | dal |
| 29. | Brandon Jacobs (27) | 49.4 | 2005-2009 | nyg |
| 30. | Fred Jackson (28) | 48.3 | 2007-2009 | buf |
| 31. | Michael Vick (29) | 46.0 | 2001-2009 | 2TM |
| 32. | Chris Brown (28) | 45.1 | 2003-2009 | 2TM |
| 33. | Michael Turner (27) | 44.5 | 2004-2009 | 2TM |
| 34. | Pierre Thomas (25) | 40.7 | 2007-2009 | nor |
| 35. | LenDale White (25) | 40.5 | 2006-2009 | oti |
| 36. | Michael Bennett (31) | 37.7 | 2001-2009 | 4TM |
| 37. | Reggie Bush (24) | 37.3 | 2006-2009 | nor |
| 38. | Mike Bell (26) | 37.2 | 2006-2009 | 2TM |
| 39. | Justin Fargas (29) | 36.6 | 2003-2009 | rai |
| 40. | Jerious Norwood (26) | 36.1 | 2006-2009 | atl |
| 41. | Chester Taylor (30) | 35.7 | 2002-2009 | 2TM |
| 42. | LaMont Jordan (31) | 33.3 | 2001-2009 | 4TM |
| 43. | Derrick Ward (29) | 33.2 | 2004-2009 | 2TM |
| 44. | Leon Washington (27) | 32.4 | 2006-2009 | nyj |
| 45. | Correll Buckhalter (31) | 31.8 | 2001-2009 | 2TM |
| 46. | Ahmad Bradshaw (23) | 31.5 | 2007-2009 | nyg |
| 47. | Tim Hightower (23) | 31.2 | 2008-2009 | crd |
| 48. | Ladell Betts (30) | 30.8 | 2002-2009 | was |
| 49. | Jerome Harrison (26) | 28.5 | 2006-2009 | cle |
| 50. | Vince Young (26) | 27.9 | 2006-2009 | oti |