| Rank | Player (age), + - HOFer, Bold - Active | Y/G | Years | Teams |
|---|---|---|---|---|
| 1. | LaDainian Tomlinson (29) | 92.6 | 2001-2008 | sdg |
| 2. | Clinton Portis (27) | 92.0 | 2002-2008 | 2TM |
| 3. | Edgerrin James (30) | 86.0 | 1999-2008 | 2TM |
| 4. | Larry Johnson (29) | 82.9 | 2003-2008 | kan |
| 5. | Jamal Lewis (29) | 82.8 | 2000-2008 | 2TM |
| 6. | Fred Taylor (32) | 80.5 | 1998-2008 | jax |
| 7. | Ricky Williams (31) | 78.5 | 1999-2008 | 2TM |
| 8. | Shaun Alexander (31) | 76.9 | 2000-2008 | 2TM |
| 9. | Willie Parker (28) | 76.8 | 2004-2008 | pit |
| 10. | Steven Jackson (25) | 76.7 | 2004-2008 | ram |
| 11. | Frank Gore (25) | 75.3 | 2005-2008 | sfo |
| 12. | Willis McGahee (27) | 70.9 | 2004-2008 | 2TM |
| 13. | Ronnie Brown (27) | 67.3 | 2005-2008 | mia |
| 14. | Ahman Green (31) | 64.6 | 1998-2008 | 3TM |
| 15. | Rudi Johnson (29) | 63.6 | 2001-2008 | 2TM |
| Cadillac Williams (26) | 63.6 | 2005-2008 | tam | |
| 17. | Deuce McAllister (30) | 62.8 | 2001-2008 | nor |
| 18. | Joseph Addai (25) | 62.7 | 2006-2008 | clt |
| 19. | Julius Jones (27) | 62.4 | 2004-2008 | 2TM |
| 20. | DeAngelo Williams (25) | 60.7 | 2006-2008 | car |
| 21. | Warrick Dunn (33) | 60.6 | 1997-2008 | 2TM |
| 22. | Thomas Jones (30) | 59.2 | 2000-2008 | 4TM |
| 23. | Brian Westbrook (29) | 57.8 | 2002-2008 | phi |
| 24. | Maurice Jones-Drew (23) | 53.9 | 2006-2008 | jax |
| 25. | Tatum Bell (27) | 52.3 | 2004-2008 | 2TM |
| 26. | Marion Barber (25) | 50.9 | 2005-2008 | dal |
| 27. | Kevin Jones (26) | 50.4 | 2004-2008 | 2TM |
| 28. | Cedric Benson (26) | 49.8 | 2005-2008 | 2TM |
| 29. | DeShaun Foster (28) | 48.2 | 2003-2008 | 2TM |
| 30. | Brandon Jacobs (26) | 47.6 | 2005-2008 | nyg |
| 31. | LenDale White (24) | 47.3 | 2006-2008 | oti |
| 32. | Reggie Bush (23) | 40.8 | 2006-2008 | nor |
| 33. | Michael Turner (26) | 39.4 | 2004-2008 | 2TM |
| 34. | Jerious Norwood (25) | 38.6 | 2006-2008 | atl |
| 35. | Michael Bennett (30) | 38.2 | 2001-2008 | 4TM |
| 36. | Chester Taylor (29) | 37.9 | 2002-2008 | 2TM |
| 37. | Michael Pittman (33) | 37.3 | 1998-2008 | 3TM |
| 38. | Justin Fargas (28) | 36.0 | 2003-2008 | rai |
| 39. | LaMont Jordan (30) | 34.7 | 2001-2008 | 3TM |
| 40. | Derrick Ward (28) | 34.3 | 2004-2008 | nyg |
| 41. | Reuben Droughns (30) | 33.0 | 2001-2008 | 4TM |
| 42. | Dominic Rhodes (29) | 32.4 | 2001-2008 | 2TM |
| 43. | Ladell Betts (29) | 31.9 | 2002-2008 | was |
| 44. | T.J. Duckett (27) | 30.9 | 2002-2008 | 4TM |
| 45. | Leon Washington (26) | 30.2 | 2006-2008 | nyj |
| 46. | Vince Young (25) | 29.5 | 2006-2008 | oti |
| 47. | Correll Buckhalter (30) | 29.1 | 2001-2008 | phi |
| 48. | Le'Ron McClain (24) | 28.8 | 2007-2008 | rav |
| 49. | Mewelde Moore (26) | 26.8 | 2004-2008 | 2TM |
| 50. | Daunte Culpepper (31) | 26.4 | 1999-2008 | 4TM |