Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Andrew Luck* | 23 | Rook | 16 | 339 for 627, 4,374 yards, 23 td, 18 int, & 62 rushes for 255 yards and 5 td | |
| RB | Vick Ballard | 22 | Rook | 12 | 211 rushes for 814 yards, 2 td, & 17 catches for 152 yards and 1 td | |
| WR | Donnie Avery | 28 | 4 | 15 | 60 catches for 781 yards, 3 td, & 4 rushes for 9 yards and 0 td | |
| WR | Reggie Wayne* | 34 | 11 | 15 | 106 catches for 1,355 yards, 5 td, & 1 rush for -5 yards and 0 td | |
| TE | Dwayne Allen | 22 | Rook | 16 | 45 catches for 521 yards, 3 td, & 3 rushes for 5 yards and 0 td | |
| TE | Coby Fleener | 24 | Rook | 10 | 26 catches for 281 yards, 2 td | |
| LT | Anthony Castonzo | 24 | 1 | 16 | 1 fumble recovered | |
| LG | Joe Reitz | 27 | 1 | 8 | ||
| C | Samson Satele | 28 | 5 | 11 | ||
| RG | Mike McGlynn | 27 | 4 | 16 | ||
| RT | Winston Justice | 28 | 5 | 12 | ||
| Defensive Starters | ||||||
| LDE | Cory Redding | 32 | 9 | 14 | 2.0 sacks, 0 interceptions, 1 fumble recovered | |
| NT | Antonio Johnson | 28 | 4 | 13 | ||
| RDE | Fili Moala | 27 | 3 | 8 | ||
| LOLB | Robert Mathis* | 31 | 9 | 12 | 8.0 sacks, 1 interception, 0 fumbles recovered | |
| LILB | Kavell Conner | 25 | 2 | 12 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RILB | Jerrell Freeman | 26 | 1 | 16 | 2.0 sacks, 1 interception, 0 fumbles recovered | |
| ROLB | Dwight Freeney | 32 | 10 | 14 | 5.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Cassius Vaughn | 25 | 2 | 11 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| RCB | Jerraud Powers | 25 | 3 | 8 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| SS | Tom Zbikowski | 27 | 4 | 11 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
| FS | Antoine Bethea | 28 | 6 | 16 | 2.0 sacks, 0 interceptions, 0 fumbles recovered |
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