Regular Season Record (all-time) : 399-394-11
Playoff Record (all-time) : 10-16 (Last appearance after 2009 season)
Super Bowls Won: 0 out of 1 appearance
Championships Won: 1
Passing Leader (all-time): Dan Fouts - 43,040 yards
Rushing Leader (all-time): LaDainian Tomlinson - 12,490 yards
Receiving Leader (all-time): Lance Alworth - 9,584 yards
Winningest Coach (all-time): Sid Gillman - 86 wins
Top Player by Approximate Value (all-time): Dan Fouts - 162 AV
| Single-season | Passing | Rushing | Receiving | Returns | Kicking | Scoring | ||
| Career | Passing | Rushing | Receiving | Returns | Kicking | Scoring | Defense | Approximate Value |
| Score | Playoffs | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Opponent | W | L | T | Tm | Opp | W | L | T | Tm | Opp | |||
| Arizona Cardinals | 9 | 3 | 0 | 0.750 | 305 | 249 | 0 | 0 | 0 | game-by-game | |||
| Atlanta Falcons | 1 | 8 | 0 | 0.111 | 97 | 183 | 0 | 0 | 0 | game-by-game | |||
| Baltimore Ravens | 4 | 5 | 0 | 0.444 | 166 | 169 | 0 | 0 | 0 | game-by-game | |||
| Buffalo Bills | 21 | 10 | 2 | 0.667 | 792 | 555 | 1 | 2 | 0 | 0.333 | 27 | 57 | game-by-game |
| Carolina Panthers | 1 | 4 | 0 | 0.200 | 77 | 119 | 0 | 0 | 0 | game-by-game | |||
| Chicago Bears | 5 | 6 | 0 | 0.455 | 213 | 182 | 0 | 0 | 0 | game-by-game | |||
| Cincinnati Bengals | 19 | 12 | 0 | 0.613 | 759 | 681 | 0 | 1 | 0 | 0.000 | 7 | 27 | game-by-game |
| Cleveland Browns | 14 | 8 | 1 | 0.630 | 546 | 441 | 0 | 0 | 0 | game-by-game | |||
| Dallas Cowboys | 3 | 6 | 0 | 0.333 | 203 | 229 | 0 | 0 | 0 | game-by-game | |||
| Denver Broncos | 48 | 57 | 1 | 0.458 | 2312 | 2258 | 0 | 0 | 0 | game-by-game | |||
| Detroit Lions | 6 | 4 | 0 | 0.600 | 211 | 222 | 0 | 0 | 0 | game-by-game | |||
| Green Bay Packers | 1 | 9 | 0 | 0.100 | 166 | 315 | 0 | 0 | 0 | game-by-game | |||
| Houston Texans | 4 | 0 | 0 | 1.000 | 115 | 56 | 0 | 0 | 0 | game-by-game | |||
| Indianapolis Colts | 15 | 9 | 0 | 0.625 | 575 | 414 | 2 | 1 | 0 | 0.667 | 71 | 76 | game-by-game |
| Jacksonville Jaguars | 3 | 2 | 0 | 0.600 | 148 | 99 | 0 | 0 | 0 | game-by-game | |||
| Kansas City Chiefs | 52 | 52 | 1 | 0.500 | 2128 | 2249 | 1 | 0 | 0 | 1.000 | 17 | 0 | game-by-game |
| Miami Dolphins | 12 | 12 | 0 | 0.500 | 558 | 525 | 2 | 2 | 0 | 0.500 | 76 | 124 | game-by-game |
| Minnesota Vikings | 6 | 5 | 0 | 0.545 | 286 | 248 | 0 | 0 | 0 | game-by-game | |||
| New England Patriots | 14 | 20 | 2 | 0.417 | 720 | 860 | 1 | 2 | 0 | 0.333 | 84 | 55 | game-by-game |
| New Orleans Saints | 7 | 4 | 0 | 0.636 | 289 | 199 | 0 | 0 | 0 | game-by-game | |||
| New York Giants | 5 | 5 | 0 | 0.500 | 255 | 245 | 0 | 0 | 0 | game-by-game | |||
| New York Jets | 20 | 12 | 1 | 0.621 | 951 | 698 | 0 | 2 | 0 | 0.000 | 31 | 37 | game-by-game |
| Oakland Raiders | 47 | 57 | 2 | 0.453 | 2279 | 2334 | 0 | 1 | 0 | 0.000 | 27 | 34 | game-by-game |
| Philadelphia Eagles | 6 | 4 | 0 | 0.600 | 178 | 186 | 0 | 0 | 0 | game-by-game | |||
| Pittsburgh Steelers | 7 | 21 | 0 | 0.250 | 505 | 719 | 2 | 1 | 0 | 0.667 | 72 | 76 | game-by-game |
| San Francisco 49ers | 6 | 6 | 0 | 0.500 | 256 | 312 | 0 | 1 | 0 | 0.000 | 26 | 49 | game-by-game |
| Seattle Seahawks | 23 | 26 | 0 | 0.469 | 1012 | 1028 | 0 | 0 | 0 | game-by-game | |||
| St. Louis Rams | 4 | 6 | 0 | 0.400 | 263 | 266 | 0 | 0 | 0 | game-by-game | |||
| Tampa Bay Buccaneers | 8 | 2 | 0 | 0.800 | 279 | 184 | 0 | 0 | 0 | game-by-game | |||
| Tennessee Titans | 25 | 13 | 1 | 0.654 | 1008 | 847 | 1 | 3 | 0 | 0.250 | 50 | 57 | game-by-game |
| Washington Redskins | 3 | 6 | 0 | 0.333 | 185 | 225 | 0 | 0 | 0 | game-by-game | |||