| Single-season | Passing | Rushing | Receiving | Returns | Kicking | Scoring | |
| Career | Passing | Rushing | Receiving | Returns | Kicking | Scoring | Defense |
| Rushing | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 1 | LaDainian Tomlinson | 2002* | 23 | SDG | RB | 16 | 16 | 372 | 1683 | 14 | 76 | 4.5 | 105.2 | 3 |
| 2 | LaDainian Tomlinson | 2006*+ | 27 | SDG | RB | 16 | 16 | 348 | 1815 | 28 | 85 | 5.2 | 113.4 | 2 |
| 3 | Natrone Means | 1994* | 22 | SDG | RB | 16 | 16 | 343 | 1350 | 12 | 25 | 3.9 | 84.4 | 5 |
| 4 | LaDainian Tomlinson | 2005* | 26 | SDG | RB | 16 | 16 | 339 | 1462 | 18 | 62 | 4.3 | 91.4 | 3 |
| 5 | LaDainian Tomlinson | 2001 | 22 | SDG | RB | 16 | 16 | 339 | 1236 | 10 | 54 | 3.6 | 77.3 | 8 |
| 6 | LaDainian Tomlinson | 2004*+ | 25 | SDG | RB | 15 | 15 | 339 | 1335 | 17 | 42 | 3.9 | 89.0 | 6 |
| 7 | LaDainian Tomlinson | 2007*+ | 28 | SDG | RB | 16 | 16 | 315 | 1474 | 15 | 49 | 4.7 | 92.1 | 0 |
| 8 | LaDainian Tomlinson | 2003 | 24 | SDG | RB | 16 | 16 | 313 | 1645 | 13 | 73 | 5.3 | 102.8 | 2 |
| 9 | Earnest Jackson | 1984* | 25 | SDG | RB | 16 | 14 | 296 | 1179 | 8 | 32 | 4.0 | 73.7 | 3 |
| 10 | LaDainian Tomlinson | 2008 | 29 | SDG | RB | 16 | 16 | 292 | 1110 | 11 | 45 | 3.8 | 69.4 | 1 |
| 11 | Mike Garrett | 1972 | 28 | SDG | RB | 14 | 0 | 272 | 1031 | 6 | 41 | 3.8 | 73.6 | 8 |
| 12 | Marion Butts | 1990* | 24 | SDG | RB | 14 | 13 | 265 | 1225 | 8 | 52 | 4.6 | 87.5 | 0 |
| 13 | Gary Brown | 1997 | 28 | SDG | RB | 15 | 14 | 253 | 945 | 4 | 32 | 3.7 | 63.0 | 2 |
| 14 | Chuck Muncie | 1981* | 28 | SDG | RB | 15 | 14 | 251 | 1144 | 19 | 73 | 4.6 | 76.3 | 9 |
| 15 | Chuck Muncie | 1983 | 30 | SDG | RB | 15 | 12 | 235 | 886 | 12 | 34 | 3.8 | 59.1 | 8 |
| 16 | Don Woods | 1974 | 23 | SDG | RB | 12 | 9 | 227 | 1162 | 7 | 56 | 5.1 | 96.8 | 4 |
| 17 | Gary W. Anderson | 1988 | 27 | SDG | RB | 14 | 13 | 225 | 1119 | 3 | 36 | 5.0 | 79.9 | 5 |
| 18 | Paul Lowe | 1965*+ | 29 | SDG | HB | 14 | 0 | 222 | 1121 | 6 | 59 | 5.0 | 80.1 | 2 |
| 19 | Leonard Russell | 1996 | 27 | SDG | RB | 15 | 15 | 219 | 713 | 7 | 21 | 3.3 | 47.5 | 6 |
| 20 | Marion Butts | 1992 | 26 | SDG | RB | 15 | 14 | 218 | 809 | 4 | 22 | 3.7 | 53.9 | 4 |
| 21 | Lydell Mitchell | 1978 | 29 | SDG | RB | 16 | 11 | 214 | 820 | 3 | 25 | 3.8 | 51.3 | 2 |
| 22 | Natrone Means | 1998 | 26 | SDG | RB | 10 | 10 | 212 | 883 | 5 | 72 | 4.2 | 88.3 | 2 |
| 23 | Clarence Williams | 1979 | 24 | SDG | FB | 16 | 16 | 200 | 752 | 12 | 55 | 3.8 | 47.0 | 1 |
| 24 | Marion Butts | 1991* | 25 | SDG | rb | 16 | 8 | 193 | 834 | 6 | 44 | 4.3 | 52.1 | 3 |
| 25 | Natrone Means | 1995 | 23 | SDG | RB | 10 | 9 | 186 | 730 | 5 | 36 | 3.9 | 73.0 | 2 |
| 26 | Marion Butts | 1993 | 27 | SDG | RB | 16 | 16 | 185 | 746 | 4 | 27 | 4.0 | 46.6 | 0 |
| 27 | Dickie Post | 1969* | 24 | SDG | HB | 14 | 0 | 182 | 873 | 6 | 60 | 4.8 | 62.4 | 3 |
| 28 | Paul Lowe | 1963* | 27 | SDG | HB | 14 | 0 | 177 | 1010 | 8 | 66 | 5.7 | 72.1 | 7 |
| 29 | Paul Lowe | 1961 | 25 | SDG | HB | 14 | 0 | 175 | 767 | 9 | 87 | 4.4 | 54.8 | 6 |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 30 | Marion Butts | 1989 | 23 | SDG | rb | 15 | 5 | 170 | 683 | 9 | 50 | 4.0 | 45.5 | 2 |
| 31 | Rickey Young | 1976 | 23 | SDG | FB | 14 | 14 | 162 | 802 | 4 | 46 | 5.0 | 57.3 | 2 |
| 32 | Dickie Post | 1967* | 22 | SDG | HB | 13 | 0 | 161 | 663 | 7 | 67 | 4.1 | 51.0 | 2 |
| 33 | Natrone Means | 1993 | 21 | SDG | rb | 16 | 0 | 160 | 645 | 8 | 65 | 4.0 | 40.3 | 1 |
| 34 | Rod Bernstine | 1991 | 26 | SDG | RB | 13 | 8 | 159 | 766 | 8 | 63 | 4.8 | 58.9 | 1 |
| 35 | Cid Edwards | 1972 | 29 | SDG | FB | 12 | 0 | 157 | 679 | 5 | 31 | 4.3 | 56.6 | 4 |
| 36 | Rickey Young | 1977 | 24 | SDG | FB | 14 | 14 | 157 | 543 | 4 | 15 | 3.5 | 38.8 | 4 |
| 37 | Keith Lincoln | 1964*+ | 25 | SDG | FB | 14 | 0 | 155 | 632 | 4 | 25 | 4.1 | 45.1 | 1 |
| 38 | Terrell Fletcher | 1998 | 25 | SDG | rb | 12 | 5 | 153 | 543 | 5 | 21 | 3.5 | 45.3 | 1 |
| 39 | Dickie Post | 1968 | 23 | SDG | HB | 13 | 0 | 151 | 758 | 3 | 62 | 5.0 | 58.3 | 0 |
| 40 | Don Woods | 1978 | 27 | SDG | FB | 16 | 7 | 151 | 514 | 3 | 27 | 3.4 | 32.1 | 5 |
| 41 | Paul Lowe | 1966 | 30 | SDG | HB | 14 | 0 | 146 | 643 | 3 | 57 | 4.4 | 45.9 | 3 |
| 42 | Mike Garrett | 1971 | 27 | SDG | RB | 13 | 0 | 140 | 591 | 4 | 36 | 4.2 | 45.5 | 6 |
| 43 | Chuck Muncie | 1982* | 29 | SDG | RB | 9 | 9 | 138 | 569 | 8 | 27 | 4.1 | 63.2 | 4 |
| 44 | Rickey Young | 1975 | 22 | SDG | RB | 14 | 8 | 138 | 577 | 5 | 48 | 4.2 | 41.2 | 5 |
| 45 | Paul Lowe | 1960+ | 24 | LAC | HB | 14 | 0 | 136 | 855 | 8 | 63 | 6.3 | 61.1 | 2 |
| 46 | Chuck Muncie | 1980 | 27 | SDG | fb | 11 | 5 | 135 | 659 | 4 | 53 | 4.9 | 59.9 | 10 |
| 47 | Tim Spencer | 1989 | 29 | SDG | RB | 16 | 11 | 134 | 521 | 3 | 15 | 3.9 | 32.6 | 3 |
| 48 | Cid Edwards | 1973 | 30 | SDG | FB | 13 | 0 | 133 | 609 | 1 | 50 | 4.6 | 46.8 | 3 |
| 49 | Paul Lowe | 1964 | 28 | SDG | HB | 14 | 0 | 130 | 496 | 3 | 50 | 3.8 | 35.4 | 2 |
| 50 | Aaron Hayden | 1995 | 22 | SDG | 7 | 4 | 128 | 470 | 3 | 20 | 3.7 | 67.1 | 0 | |
| 51 | Keith Lincoln | 1963*+ | 24 | SDG | FB | 14 | 0 | 128 | 826 | 5 | 76 | 6.5 | 59.0 | 5 |
| 52 | Gary W. Anderson | 1986* | 25 | SDG | RB | 16 | 12 | 127 | 442 | 1 | 17 | 3.5 | 27.6 | 5 |
| 53 | James Brooks | 1983 | 25 | SDG | rb | 15 | 5 | 127 | 516 | 3 | 61 | 4.1 | 34.4 | 8 |
| 54 | Howie Ferguson | 1960 | 30 | LAC | FB | 14 | 0 | 126 | 438 | 4 | 30 | 3.5 | 31.3 | 6 |
| 55 | Don Woods | 1976 | 25 | SDG | RB | 11 | 10 | 126 | 450 | 3 | 24 | 3.6 | 40.9 | 1 |
| 56 | Rod Bernstine | 1990 | 25 | SDG | 12 | 1 | 124 | 589 | 4 | 40 | 4.8 | 49.1 | 1 | |
| 57 | Tim Spencer | 1985 | 25 | SDG | FB | 16 | 15 | 124 | 478 | 10 | 24 | 3.9 | 29.9 | 1 |
| 58 | Gene Foster | 1965 | 23 | SDG | FB | 14 | 0 | 121 | 469 | 2 | 22 | 3.9 | 33.5 | 2 |
| 59 | Jermaine Fazande | 2000 | 25 | SDG | RB | 13 | 7 | 119 | 368 | 2 | 26 | 3.1 | 28.3 | 1 |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 60 | Curtis Adams | 1986 | 24 | SDG | 7 | 2 | 118 | 366 | 4 | 22 | 3.1 | 52.3 | 3 | |
| 61 | Mike Thomas | 1980 | 27 | SDG | rb | 10 | 5 | 118 | 484 | 3 | 18 | 4.1 | 48.4 | 0 |
| 62 | Don Woods | 1977 | 26 | SDG | RB | 14 | 14 | 118 | 405 | 1 | 29 | 3.4 | 28.9 | 2 |
| 63 | Keith Lincoln | 1962* | 23 | SDG | HB | 14 | 0 | 117 | 574 | 2 | 86 | 4.9 | 41.0 | 1 |
| 64 | Gary W. Anderson | 1985 | 24 | SDG | rb | 12 | 6 | 116 | 429 | 4 | 27 | 3.7 | 35.8 | 5 |
| 65 | Terrell Fletcher | 2000 | 27 | SDG | rb | 16 | 6 | 116 | 384 | 3 | 21 | 3.3 | 24.0 | 2 |
| 66 | Brad Hubbert | 1967* | 26 | SDG | FB | 14 | 0 | 116 | 643 | 2 | 80 | 5.5 | 45.9 | 1 |
| 67 | LaDainian Tomlinson | 2009 | 30 | SDG | 7 | 115 | 385 | 5 | 36 | 3.3 | 55.0 | 1 | ||
| 68 | Mike Garrett | 1973 | 29 | SDG | RB | 10 | 0 | 114 | 467 | 0 | 68 | 4.1 | 46.7 | 6 |
| 69 | Natrone Means | 1999 | 27 | SDG | RB | 7 | 5 | 112 | 277 | 4 | 15 | 2.5 | 39.6 | 0 |
| 70 | James Brooks | 1981 | 23 | SDG | RET | 14 | 2 | 109 | 525 | 3 | 28 | 4.8 | 37.5 | 7 |
| 71 | Gene Foster | 1968 | 26 | SDG | FB | 10 | 0 | 109 | 394 | 1 | 22 | 3.6 | 39.4 | 2 |
| 72 | Rod Bernstine | 1992 | 27 | SDG | 9 | 1 | 106 | 499 | 4 | 25 | 4.7 | 55.4 | 2 | |
| 73 | Bobby Jackson | 1962 | 22 | SDG | FB | 14 | 0 | 106 | 411 | 5 | 19 | 3.9 | 29.4 | 0 |
| 74 | Lionel James | 1985 | 23 | SDG | RB | 16 | 7 | 105 | 516 | 2 | 56 | 4.9 | 32.3 | 9 |
| 75 | John Cappelletti | 1980 | 28 | SDG | FB | 10 | 8 | 101 | 364 | 5 | 46 | 3.6 | 36.4 | 1 |
| 76 | Tim Spencer | 1986 | 26 | SDG | FB | 14 | 12 | 99 | 350 | 6 | 23 | 3.5 | 25.0 | 2 |
| 77 | Clarence Williams | 1980 | 25 | SDG | RB | 13 | 9 | 97 | 258 | 3 | 13 | 2.7 | 19.8 | 3 |
| 78 | Bo Matthews | 1974 | 23 | SDG | FB | 14 | 8 | 95 | 328 | 4 | 16 | 3.5 | 23.4 | 2 |
| 79 | Jeff Queen | 1971 | 25 | SDG | FB | 14 | 0 | 95 | 318 | 4 | 41 | 3.3 | 22.7 | 4 |
| 80 | Brad Hubbert | 1969 | 28 | SDG | FB | 14 | 0 | 94 | 333 | 4 | 24 | 3.5 | 23.8 | 5 |
| 81 | Kenny Bynum | 1999 | 25 | SDG | rb | 16 | 5 | 92 | 287 | 1 | 25 | 3.1 | 17.9 | 3 |
| 82 | Jermaine Fazande | 1999 | 24 | SDG | 7 | 3 | 91 | 365 | 2 | 54 | 4.0 | 52.1 | 2 | |
| 83 | Mike Thomas | 1979 | 26 | SDG | RB | 14 | 9 | 91 | 353 | 1 | 21 | 3.9 | 25.2 | 4 |
| 84 | Curtis Adams | 1987 | 25 | SDG | 12 | 4 | 90 | 343 | 1 | 24 | 3.8 | 28.6 | 1 | |
| 85 | Ronnie Harmon | 1991 | 27 | SDG | 16 | 0 | 89 | 544 | 1 | 33 | 6.1 | 34.0 | 2 | |
| 86 | Russ Smith | 1968 | 24 | SDG | fb | 14 | 0 | 88 | 426 | 4 | 37 | 4.8 | 30.4 | 4 |
| 87 | James Brooks | 1982 | 24 | SDG | RET | 9 | 0 | 87 | 430 | 6 | 48 | 4.9 | 47.8 | 4 |
| 88 | Don Woods | 1975 | 24 | SDG | rb | 5 | 5 | 87 | 317 | 2 | 17 | 3.6 | 63.4 | 1 |
| 89 | Hank Bauer | 1978 | 24 | SDG | 16 | 4 | 85 | 304 | 8 | 37 | 3.6 | 19.0 | 2 | |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 90 | Gene Foster | 1966 | 24 | SDG | FB | 14 | 0 | 81 | 352 | 1 | 37 | 4.3 | 25.1 | 2 |
| 91 | Gary W. Anderson | 1987 | 26 | SDG | RB | 12 | 7 | 80 | 260 | 3 | 25 | 3.3 | 21.7 | 4 |
| 92 | Michael Turner | 2006 | 24 | SDG | RET | 13 | 0 | 80 | 502 | 2 | 73 | 6.3 | 38.6 | 0 |
| 93 | Robert Holmes | 1973 | 28 | SDG | 13 | 0 | 78 | 289 | 7 | 24 | 3.7 | 22.2 | 5 | |
| 94 | Terrell Fletcher | 1996 | 23 | SDG | 16 | 0 | 77 | 282 | 0 | 19 | 3.7 | 17.6 | 1 | |
| 95 | Jeff Queen | 1970 | 24 | SDG | FB | 14 | 0 | 77 | 261 | 1 | 19 | 3.4 | 18.6 | 4 |
| 96 | Eric Bieniemy | 1992 | 23 | SDG | RET | 15 | 0 | 74 | 264 | 3 | 21 | 3.6 | 17.6 | 4 |
| 97 | Keith Lincoln | 1965* | 26 | SDG | fb | 10 | 0 | 74 | 302 | 3 | 24 | 4.1 | 30.2 | 0 |
| 98 | Dickie Post | 1970 | 25 | SDG | RB | 9 | 0 | 74 | 225 | 1 | 18 | 3.0 | 25.0 | 1 |
| 99 | Eric Bieniemy | 1994 | 25 | SDG | 16 | 0 | 73 | 295 | 0 | 36 | 4.0 | 18.4 | 1 | |
| 100 | Tim Spencer | 1987 | 27 | SDG | FB | 12 | 7 | 73 | 228 | 0 | 16 | 3.1 | 19.0 | 1 |
| 101 | Bo Matthews | 1975 | 24 | SDG | FB | 13 | 12 | 71 | 254 | 3 | 24 | 3.6 | 19.5 | 6 |
| 102 | Bo Matthews | 1978 | 27 | SDG | fb | 11 | 9 | 71 | 286 | 0 | 28 | 4.0 | 26.0 | 5 |
| 103 | Michael Turner | 2007 | 25 | SDG | 16 | 0 | 71 | 316 | 1 | 74 | 4.5 | 19.8 | 1 | |
| 104 | John Cappelletti | 1981 | 29 | SDG | fb | 16 | 5 | 68 | 254 | 4 | 30 | 3.7 | 15.9 | 3 |
| 105 | Buford McGee | 1984 | 24 | SDG | 16 | 0 | 67 | 226 | 4 | 30 | 3.4 | 14.1 | 1 | |
| 106 | Glen Bonner | 1974 | 22 | SDG | 12 | 3 | 66 | 199 | 3 | 12 | 3.0 | 16.6 | 3 | |
| 107 | Ronnie Harmon | 1990 | 26 | SDG | 16 | 2 | 66 | 363 | 0 | 41 | 5.5 | 22.7 | 1 | |
| 108 | Jesse Chatman | 2004 | 25 | SDG | 15 | 0 | 65 | 392 | 3 | 52 | 6.0 | 26.1 | 1 | |
| 109 | Cid Edwards | 1974 | 31 | SDG | 10 | 0 | 65 | 261 | 0 | 30 | 4.0 | 26.1 | 2 | |
| 110 | Gene Foster | 1969 | 27 | SDG | 13 | 0 | 64 | 236 | 0 | 24 | 3.7 | 18.2 | 3 | |
| 111 | Buford McGee | 1986 | 26 | SDG | 9 | 3 | 63 | 187 | 7 | 20 | 3.0 | 20.8 | 4 | |
| 112 | Lydell Mitchell | 1979 | 30 | SDG | rb | 12 | 5 | 63 | 211 | 0 | 15 | 3.3 | 17.6 | 2 |
| 113 | Joe Washington | 1977 | 24 | SDG | 13 | 0 | 62 | 217 | 0 | 19 | 3.5 | 16.7 | 1 | |
| 114 | Leon Burns | 1971 | 31 | SDG | 14 | 0 | 61 | 223 | 1 | 25 | 3.7 | 15.9 | 2 | |
| 115 | Sam Scarber | 1976 | 27 | SDG | 14 | 2 | 61 | 236 | 1 | 14 | 3.9 | 16.9 | 3 | |
| 116 | Darren Sproles | 2008 | 25 | SDG | RET | 16 | 0 | 61 | 330 | 1 | 37 | 5.4 | 20.6 | 3 |
| 117 | Mike Montgomery | 1971 | 22 | SDG | 11 | 0 | 60 | 226 | 1 | 26 | 3.8 | 20.5 | 4 | |
| 118 | Jacque MacKinnon | 1962 | 24 | SDG | 14 | 0 | 59 | 240 | 0 | 24 | 4.1 | 17.1 | 2 | |
| 119 | Keith Lincoln | 1966 | 27 | SDG | 14 | 0 | 58 | 214 | 1 | 23 | 3.7 | 15.3 | 1 | |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 120 | Bo Roberson | 1961 | 26 | SDG | RET | 14 | 0 | 58 | 275 | 3 | 59 | 4.7 | 19.6 | 3 |
| 121 | Michael Turner | 2005 | 23 | SDG | 16 | 0 | 57 | 335 | 3 | 83 | 5.9 | 20.9 | 0 | |
| 122 | Ronnie Harmon | 1992* | 28 | SDG | rb | 16 | 2 | 55 | 235 | 3 | 33 | 4.3 | 14.7 | 4 |
| 123 | Aaron Hayden | 1996 | 23 | SDG | 11 | 0 | 55 | 166 | 0 | 13 | 3.0 | 15.1 | 1 | |
| 124 | Clint Jones | 1973 | 28 | SDG | rb | 12 | 5 | 55 | 170 | 1 | 38 | 3.1 | 14.2 | 2 |
| 125 | Jack Kemp | 1960+ | 25 | LAC | QB | 14 | 12 | 54 | 238 | 8 | 8 | 4.4 | 17.0 | 9 |
| 126 | Drew Brees | 2004* | 25 | SDG | QB | 15 | 15 | 53 | 85 | 2 | 22 | 1.6 | 5.7 | 7 |
| 127 | Doug Flutie | 2001 | 39 | SDG | QB | 16 | 16 | 53 | 192 | 1 | 16 | 3.6 | 12.0 | 7 |
| 128 | Russ Smith | 1970 | 26 | SDG | 12 | 0 | 52 | 163 | 3 | 21 | 3.1 | 13.6 | 1 | |
| 129 | Terrell Fletcher | 1997 | 24 | SDG | 13 | 1 | 51 | 161 | 0 | 13 | 3.2 | 12.4 | 4 | |
| 130 | Charlie Flowers | 1961 | 24 | SDG | FB | 14 | 0 | 51 | 177 | 3 | 11 | 3.5 | 12.6 | 2 |
| 131 | Ronnie Harmon | 1995 | 31 | SDG | 16 | 1 | 51 | 187 | 1 | 48 | 3.7 | 11.7 | 1 | |
| 132 | Lionel James | 1986 | 24 | SDG | 7 | 1 | 51 | 224 | 0 | 24 | 4.4 | 32.0 | 5 | |
| 133 | Russ Smith | 1969 | 25 | SDG | 14 | 0 | 51 | 211 | 2 | 16 | 4.1 | 15.1 | 0 | |
| 134 | Darren Sproles | 2009 | 26 | SDG | 9 | 51 | 184 | 1 | 21 | 3.6 | 20.4 | 2 | ||
| 135 | Mercury Morris | 1976 | 29 | SDG | 13 | 0 | 50 | 256 | 2 | 30 | 5.1 | 19.7 | 1 | |
| 136 | Clarence Williams | 1977 | 22 | SDG | RET | 14 | 0 | 50 | 215 | 2 | 46 | 4.3 | 15.4 | 2 |
| 137 | Brad Hubbert | 1970 | 29 | SDG | 8 | 0 | 49 | 175 | 1 | 11 | 3.6 | 21.9 | 0 | |
| 138 | Terrell Fletcher | 1999 | 26 | SDG | 15 | 2 | 48 | 126 | 0 | 16 | 2.6 | 8.4 | 1 | |
| 139 | Philip Rivers | 2006* | 25 | SDG | QB | 16 | 16 | 48 | 49 | 0 | 15 | 1.0 | 3.1 | 8 |
| 140 | Rodney Culver | 1995 | 26 | SDG | 8 | 2 | 47 | 155 | 3 | 17 | 3.3 | 19.4 | 0 | |
| 141 | Mike Garrett | 1970 | 26 | SDG | 9 | 0 | 46 | 146 | 1 | 22 | 3.2 | 16.2 | 3 | |
| 142 | Ronnie Harmon | 1993 | 29 | SDG | 16 | 1 | 46 | 216 | 0 | 19 | 4.7 | 13.5 | 0 | |
| 143 | Bo Matthews | 1976 | 25 | SDG | 12 | 2 | 46 | 199 | 3 | 42 | 4.3 | 16.6 | 3 | |
| 144 | Tim Spencer | 1988 | 28 | SDG | 16 | 1 | 44 | 215 | 0 | 24 | 4.9 | 13.4 | 0 | |
| 145 | Jack Kemp | 1961* | 26 | SDG | QB | 14 | 14 | 43 | 105 | 6 | 23 | 2.4 | 7.5 | 10 |
| 146 | Bo Matthews | 1977 | 26 | SDG | 12 | 0 | 43 | 193 | 0 | 22 | 4.5 | 16.1 | 0 | |
| 147 | Gerry McDougall | 1962 | 27 | SDG | 4 | 0 | 43 | 197 | 3 | 24 | 4.6 | 49.3 | 1 | |
| 148 | Tony Baker | 1975 | 30 | SDG | 13 | 1 | 42 | 131 | 1 | 18 | 3.1 | 10.1 | 1 | |
| 149 | Robert Chancey | 2000 | 28 | SDG | 4 | 3 | 42 | 141 | 2 | 14 | 3.4 | 35.3 | 0 | |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 150 | Buford McGee | 1985 | 25 | SDG | 11 | 1 | 42 | 181 | 3 | 44 | 4.3 | 16.5 | 4 | |
| 151 | Keith Lincoln | 1961 | 22 | SDG | 14 | 0 | 41 | 150 | 0 | 17 | 3.7 | 10.7 | 0 | |
| 152 | John Hadl | 1962 | 22 | SDG | QB | 14 | 10 | 40 | 139 | 1 | 18 | 3.5 | 9.9 | 8 |
| 153 | Artie Owens | 1979 | 26 | SDG | RET | 16 | 2 | 40 | 151 | 1 | 23 | 3.8 | 9.4 | 1 |
| 154 | Charlie Flowers | 1960 | 23 | LAC | 10 | 0 | 39 | 161 | 1 | 25 | 4.1 | 16.1 | 2 | |
| 155 | Curtis Adams | 1988 | 26 | SDG | 7 | 1 | 38 | 149 | 1 | 14 | 3.9 | 21.3 | 1 | |
| 156 | Drew Brees | 2002 | 23 | SDG | QB | 16 | 16 | 38 | 130 | 1 | 15 | 3.4 | 8.1 | 2 |
| 157 | Gene Foster | 1967 | 25 | SDG | 10 | 0 | 38 | 78 | 0 | 13 | 2.1 | 7.8 | 1 | |
| 158 | John Hadl | 1966 | 26 | SDG | QB | 14 | 13 | 38 | 95 | 2 | 21 | 2.5 | 6.8 | 4 |
| 159 | Gerry McDougall | 1963 | 28 | SDG | 14 | 0 | 38 | 199 | 1 | 22 | 5.2 | 14.2 | 1 | |
| 160 | John Hadl | 1967 | 27 | SDG | QB | 14 | 14 | 37 | 107 | 3 | 26 | 2.9 | 7.6 | 6 |
| 161 | Mark Malone | 1988 | 30 | SDG | QB | 12 | 8 | 37 | 169 | 4 | 36 | 4.6 | 14.1 | 6 |
| 162 | Darren Sproles | 2007 | 24 | SDG | RET | 15 | 0 | 37 | 164 | 2 | 34 | 4.4 | 10.9 | 1 |
| 163 | Darrin Nelson | 1989 | 30 | SDG | 9 | 0 | 36 | 197 | 0 | 28 | 5.5 | 21.9 | 1 | |
| 164 | Tremayne Stephens | 1998 | 22 | SDG | 13 | 1 | 35 | 122 | 1 | 12 | 3.5 | 9.4 | 1 | |
| 165 | Jim Harbaugh | 1999 | 36 | SDG | QB | 14 | 12 | 34 | 126 | 0 | 16 | 3.7 | 9.0 | 12 |
| 166 | Eric Bieniemy | 1993 | 24 | SDG | 16 | 0 | 33 | 135 | 1 | 12 | 4.1 | 8.4 | 1 | |
| 167 | Doug Flutie | 2003 | 41 | SDG | qb | 7 | 5 | 33 | 168 | 2 | 17 | 5.1 | 24.0 | 7 |
| 168 | Stan Humphries | 1995 | 30 | SDG | QB | 15 | 15 | 33 | 53 | 1 | 18 | 1.6 | 3.5 | 9 |
| 169 | Freddie Bradley | 1996 | 26 | SDG | 10 | 1 | 32 | 109 | 0 | 17 | 3.4 | 10.9 | 0 | |
| 170 | Gene Foster | 1970 | 28 | SDG | 7 | 0 | 32 | 84 | 0 | 15 | 2.6 | 12.0 | 1 | |
| 171 | Jim Allison | 1966 | 23 | SDG | 14 | 0 | 31 | 213 | 2 | 61 | 6.9 | 15.2 | 1 | |
| 172 | Babe Laufenberg | 1988 | 29 | SDG | qb | 8 | 6 | 31 | 120 | 0 | 23 | 3.9 | 15.0 | 2 |
| 173 | Philip Rivers | 2008 | 27 | SDG | QB | 16 | 16 | 31 | 84 | 0 | 11 | 2.7 | 5.3 | 8 |
| 174 | Kenny Bynum | 1997 | 23 | SDG | RET | 13 | 0 | 30 | 97 | 0 | 19 | 3.2 | 7.5 | 0 |
| 175 | Bo Matthews | 1979 | 28 | SDG | 16 | 0 | 30 | 112 | 1 | 22 | 3.7 | 7.0 | 1 | |
| 176 | Jim Allison | 1965 | 22 | SDG | 14 | 0 | 29 | 100 | 0 | 17 | 3.4 | 7.1 | 0 | |
| 177 | Terrell Fletcher | 2001 | 28 | SDG | 13 | 0 | 29 | 107 | 0 | 16 | 3.7 | 8.2 | 1 | |
| 178 | Jim McMahon | 1989 | 30 | SDG | QB | 12 | 11 | 29 | 141 | 0 | 15 | 4.9 | 11.8 | 3 |
| 179 | Lorenzo Neal | 2006*+ | 36 | SDG | FB | 16 | 11 | 29 | 140 | 1 | 43 | 4.8 | 8.8 | 2 |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 180 | Lorenzo Neal | 2005* | 35 | SDG | FB | 16 | 15 | 29 | 98 | 0 | 9 | 3.4 | 6.1 | 0 |
| 181 | Philip Rivers | 2007 | 26 | SDG | QB | 16 | 16 | 29 | 33 | 1 | 10 | 1.1 | 2.1 | 11 |
| 182 | Glen Bonner | 1975 | 23 | SDG | 10 | 1 | 28 | 120 | 0 | 12 | 4.3 | 12.0 | 0 | |
| 183 | John Hadl | 1965* | 25 | SDG | QB | 14 | 14 | 28 | 91 | 1 | 23 | 3.3 | 6.5 | 9 |
| 184 | John Hadl | 1970 | 30 | SDG | QB | 14 | 12 | 28 | 188 | 1 | 34 | 6.7 | 13.4 | 3 |
| 185 | Brad Hubbert | 1968 | 27 | SDG | 2 | 0 | 28 | 119 | 2 | 21 | 4.3 | 59.5 | 0 | |
| 186 | Stan Humphries | 1992 | 27 | SDG | QB | 16 | 15 | 28 | 79 | 4 | 25 | 2.8 | 4.9 | 9 |
| 187 | Ryan Leaf | 2000 | 24 | SDG | QB | 11 | 9 | 28 | 54 | 0 | 14 | 1.9 | 4.9 | 12 |
| 188 | Paul Lowe | 1967 | 31 | SDG | 7 | 0 | 28 | 71 | 1 | 21 | 2.5 | 10.1 | 0 | |
| 189 | Frank Middleton | 1987 | 27 | SDG | 3 | 2 | 28 | 74 | 1 | 21 | 2.6 | 24.7 | 0 | |
| 190 | Lionel James | 1987 | 25 | SDG | WR | 12 | 11 | 27 | 102 | 2 | 15 | 3.8 | 8.5 | 6 |
| 191 | Ryan Leaf | 1998 | 22 | SDG | qb | 10 | 9 | 27 | 80 | 0 | 20 | 3.0 | 8.0 | 8 |
| 192 | Clarence Williams | 1978 | 23 | SDG | 10 | 1 | 27 | 76 | 0 | 12 | 2.8 | 7.6 | 0 | |
| 193 | Terrell Fletcher | 2002 | 29 | SDG | 10 | 0 | 26 | 128 | 1 | 15 | 4.9 | 12.8 | 0 | |
| 194 | Terrell Fletcher | 1995 | 22 | SDG | 16 | 0 | 26 | 140 | 1 | 46 | 5.4 | 8.8 | 2 | |
| 195 | Dan Fouts | 1979*+ | 28 | SDG | QB | 16 | 16 | 26 | 49 | 2 | 26 | 1.9 | 3.1 | 13 |
| 196 | John Hadl | 1969* | 29 | SDG | QB | 14 | 10 | 26 | 109 | 2 | 17 | 4.2 | 7.8 | 3 |
| 197 | Ronnie Harmon | 1994 | 30 | SDG | 16 | 0 | 25 | 94 | 1 | 15 | 3.8 | 5.9 | 0 | |
| 198 | Lionel James | 1984 | 22 | SDG | RET | 16 | 2 | 25 | 115 | 0 | 20 | 4.6 | 7.2 | 9 |
| 199 | Larry Barnes | 1977 | 23 | SDG | 5 | 0 | 24 | 70 | 0 | 7 | 2.9 | 14.0 | 0 | |
| 200 | Keith Kinderman | 1964 | 24 | SDG | 8 | 0 | 24 | 111 | 0 | 22 | 4.6 | 13.9 | 0 | |
| 201 | Jacque MacKinnon | 1964 | 26 | SDG | 14 | 0 | 24 | 124 | 2 | 48 | 5.2 | 8.9 | 0 | |
| 202 | Tobin Rote | 1963*+ | 35 | SDG | QB | 14 | 14 | 24 | 62 | 2 | 15 | 2.6 | 4.4 | 2 |
| 203 | Sherman Smith | 1983 | 29 | SDG | 13 | 2 | 24 | 91 | 0 | 20 | 3.8 | 7.0 | 2 | |
| 204 | Tremayne Stephens | 1999 | 23 | SDG | 11 | 2 | 24 | 61 | 3 | 9 | 2.5 | 5.5 | 2 | |
| 205 | Jim Allison | 1968 | 25 | SDG | 12 | 0 | 23 | 31 | 0 | 6 | 1.3 | 2.6 | 0 | |
| 206 | Dan Fouts | 1975 | 24 | SDG | QB | 10 | 9 | 23 | 170 | 2 | 32 | 7.4 | 17.0 | 3 |
| 207 | Dan Fouts | 1980* | 29 | SDG | QB | 16 | 16 | 23 | 15 | 2 | 9 | 0.7 | 0.9 | 11 |
| 208 | John Hadl | 1968* | 28 | SDG | QB | 14 | 14 | 23 | 14 | 2 | 9 | 0.6 | 1.0 | 6 |
| 209 | Lionel James | 1988 | 26 | SDG | RET | 16 | 1 | 23 | 105 | 0 | 23 | 4.6 | 6.6 | 3 |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 210 | Gerry McDougall | 1964 | 29 | SDG | 7 | 0 | 23 | 73 | 2 | 24 | 3.2 | 10.4 | 2 | |
| 211 | Lee White | 1972 | 26 | SDG | 8 | 0 | 23 | 75 | 0 | 12 | 3.3 | 9.4 | 0 | |
| 212 | Hank Bauer | 1979 | 25 | SDG | 16 | 0 | 22 | 28 | 8 | 6 | 1.3 | 1.8 | 1 | |
| 213 | John Cappelletti | 1982 | 30 | SDG | FB | 9 | 6 | 22 | 82 | 0 | 17 | 3.7 | 9.1 | 1 |
| 214 | Dan Fouts | 1981* | 30 | SDG | QB | 16 | 16 | 22 | 56 | 0 | 13 | 2.5 | 3.5 | 9 |
| 215 | John Hadl | 1972* | 32 | SDG | QB | 14 | 14 | 22 | 99 | 1 | 17 | 4.5 | 7.1 | 7 |
| 216 | Keyvan Jenkins | 1987 | 26 | SDG | 3 | 2 | 22 | 88 | 0 | 9 | 4.0 | 29.3 | 0 | |
| 217 | Russ Smith | 1967 | 23 | SDG | 12 | 0 | 22 | 115 | 1 | 16 | 5.2 | 9.6 | 0 | |
| 218 | Bob L. Thomas | 1973 | 25 | SDG | 14 | 0 | 22 | 48 | 0 | 12 | 2.2 | 3.4 | 3 | |
| 219 | Drew Brees | 2005 | 26 | SDG | QB | 16 | 16 | 21 | 49 | 1 | 9 | 2.3 | 3.1 | 8 |
| 220 | Drew Brees | 2003 | 24 | SDG | QB | 11 | 11 | 21 | 84 | 0 | 18 | 4.0 | 7.6 | 5 |
| 221 | Stan Humphries | 1996 | 31 | SDG | QB | 13 | 13 | 21 | 28 | 0 | 7 | 1.3 | 2.2 | 7 |
| 222 | Bob L. Thomas | 1974 | 26 | SDG | 14 | 2 | 21 | 56 | 0 | 12 | 2.7 | 4.0 | 0 | |
| 223 | Aaron Craver | 1997 | 29 | SDG | fb | 15 | 5 | 20 | 71 | 0 | 22 | 3.6 | 4.7 | 0 |
| 224 | Fred Ford | 1960 | 22 | LAC | 6 | 0 | 20 | 154 | 2 | 53 | 7.7 | 25.7 | 0 | |
| 225 | Dan Fouts | 1978 | 27 | SDG | QB | 15 | 14 | 20 | 43 | 2 | 22 | 2.2 | 2.9 | 10 |
| 226 | John Hadl | 1964* | 24 | SDG | QB | 14 | 9 | 20 | 70 | 1 | 20 | 3.5 | 5.0 | 6 |
| 227 | Michael Turner | 2004 | 22 | SDG | 14 | 1 | 20 | 104 | 0 | 30 | 5.2 | 7.4 | 1 | |
| 228 | Clarence Williams | 1981 | 26 | SDG | 14 | 1 | 20 | 26 | 0 | 6 | 1.3 | 1.9 | 2 | |
| 229 | Marty Domres | 1969 | 22 | SDG | 10 | 4 | 19 | 145 | 4 | 22 | 7.6 | 14.5 | 0 | |
| 230 | Dan Fouts | 1974 | 23 | SDG | QB | 11 | 11 | 19 | 63 | 1 | 16 | 3.3 | 5.7 | 4 |
| 231 | Jacob Hester | 2008 | 23 | SDG | 16 | 3 | 19 | 95 | 1 | 28 | 5.0 | 5.9 | 1 | |
| 232 | Stan Humphries | 1994 | 29 | SDG | QB | 15 | 15 | 19 | 19 | 0 | 8 | 1.0 | 1.3 | 6 |
| 233 | Pete Johnson | 1984 | 30 | SDG | 3 | 0 | 19 | 46 | 3 | 7 | 2.4 | 15.3 | 0 | |
| 234 | Barry Redden | 1988 | 28 | SDG | 8 | 2 | 19 | 30 | 3 | 5 | 1.6 | 3.8 | 0 | |
| 235 | Martin Sartin | 1987 | 24 | SDG | 3 | 1 | 19 | 52 | 1 | 10 | 2.7 | 17.3 | 2 | |
| 236 | Dan Fouts | 1976 | 25 | SDG | QB | 14 | 13 | 18 | 65 | 0 | 13 | 3.6 | 4.6 | 8 |
| 237 | John Hadl | 1971 | 31 | SDG | QB | 14 | 14 | 18 | 75 | 1 | 37 | 4.2 | 5.4 | 4 |
| 238 | Mark Herrmann | 1985 | 26 | SDG | qb | 9 | 4 | 18 | -8 | 0 | 11 | -0.4 | -0.9 | 8 |
| 239 | Bobby Jackson | 1963 | 23 | SDG | 12 | 0 | 18 | 64 | 4 | 14 | 3.6 | 5.3 | 1 | |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 240 | Lorenzo Neal | 2003 | 33 | SDG | FB | 16 | 15 | 18 | 40 | 1 | 7 | 2.2 | 2.5 | 0 |
| 241 | Craig Whelihan | 1998 | 27 | SDG | QB | 10 | 7 | 18 | 38 | 0 | 13 | 2.1 | 3.8 | 9 |
| 242 | Hezekiah Braxton | 1962 | 26 | SDG | 8 | 0 | 17 | 35 | 1 | 15 | 2.1 | 4.4 | 0 | |
| 243 | Dana Brinson | 1989 | 24 | SDG | 10 | 0 | 17 | 64 | 0 | 9 | 3.8 | 6.4 | 3 | |
| 244 | Curtis Adams | 1985 | 23 | SDG | 1 | 0 | 16 | 49 | 1 | 14 | 3.1 | 49.0 | 0 | |
| 245 | Hunter Enis | 1961 | 25 | SDG | 13 | 0 | 16 | 13 | 2 | 9 | 0.8 | 1.0 | 4 | |
| 246 | Jim Harbaugh | 2000 | 37 | SDG | qb | 7 | 5 | 16 | 24 | 0 | 7 | 1.5 | 3.4 | 5 |
| 247 | Lorenzo Neal | 2004 | 34 | SDG | FB | 16 | 10 | 16 | 53 | 0 | 8 | 3.3 | 3.3 | 1 |
| 248 | Philip Rivers | 2009 | 28 | SDG | 9 | 16 | 46 | 1 | 15 | 2.9 | 5.1 | 6 | ||
| 249 | Rod Bernstine | 1989 | 24 | SDG | 5 | 0 | 15 | 137 | 1 | 32 | 9.1 | 27.4 | 0 | |
| 250 | Sam Scarber | 1975 | 26 | SDG | 11 | 1 | 15 | 68 | 1 | 18 | 4.5 | 6.2 | 2 | |
| 251 | Marty Domres | 1970 | 23 | SDG | 8 | 2 | 14 | 39 | 0 | 7 | 2.8 | 4.9 | 2 | |
| 252 | Chuck Muncie | 1984 | 31 | SDG | 1 | 1 | 14 | 51 | 0 | 11 | 3.6 | 51.0 | 1 | |
| 253 | Ron Sayers | 1969 | 22 | SDG | 8 | 0 | 14 | 53 | 0 | 8 | 3.8 | 6.6 | 1 | |
| 254 | Dave Smith | 1970 | 23 | SDG | 7 | 0 | 14 | 42 | 0 | 15 | 3.0 | 6.0 | 0 | |
| 255 | Todd Spencer | 1987 | 25 | SDG | 3 | 2 | 14 | 24 | 0 | 5 | 1.7 | 8.0 | 2 | |
| 256 | Jewerl Thomas | 1984 | 27 | SDG | 7 | 0 | 14 | 43 | 2 | 9 | 3.1 | 6.1 | 1 | |
| 257 | Billy Joe Tolliver | 1990 | 24 | SDG | QB | 15 | 14 | 14 | 22 | 0 | 14 | 1.6 | 1.5 | 6 |
| 258 | Wayne Clark | 1973 | 26 | SDG | 11 | 4 | 13 | 86 | 0 | 16 | 6.6 | 7.8 | 1 | |
| 259 | Stan Humphries | 1997 | 32 | SDG | QB | 8 | 8 | 13 | 24 | 0 | 11 | 1.8 | 3.0 | 7 |
| 260 | Lorenzo Neal | 2007*+ | 37 | SDG | FB | 13 | 8 | 13 | 32 | 0 | 10 | 2.5 | 2.5 | 1 |
| 261 | Jesse Taylor | 1972 | 24 | SDG | RET | 14 | 0 | 13 | 58 | 0 | 17 | 4.5 | 4.1 | 3 |
| 262 | Mike Tolbert | 2008 | 23 | SDG | fb | 13 | 7 | 13 | 37 | 0 | 11 | 2.8 | 2.8 | 0 |
| 263 | Craig Whelihan | 1997 | 26 | SDG | qb | 9 | 7 | 13 | 29 | 0 | 7 | 2.2 | 3.2 | 7 |
| 264 | Michael Bennett | 2009 | 31 | SDG | 3 | 12 | 37 | 0 | 9 | 3.1 | 12.3 | 0 | ||
| 265 | Bert Coan | 1962 | 22 | SDG | 4 | 0 | 12 | 10 | 0 | 8 | 0.8 | 2.5 | 0 | |
| 266 | Tim Dwight | 2002 | 27 | SDG | WR | 16 | 14 | 12 | 108 | 1 | 20 | 9.0 | 6.8 | 1 |
| 267 | Dan Fouts | 1983* | 32 | SDG | QB | 10 | 10 | 12 | -5 | 1 | 3 | -0.4 | -0.5 | 5 |
| 268 | Dan Fouts | 1984 | 33 | SDG | QB | 13 | 13 | 12 | -29 | 0 | 3 | -2.4 | -2.2 | 8 |
| 269 | Dan Fouts | 1987 | 36 | SDG | QB | 11 | 10 | 12 | 0 | 2 | 2 | 0.0 | 0.0 | 10 |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 270 | Kenny Bynum | 1998 | 24 | SDG | RET | 10 | 0 | 11 | 23 | 0 | 14 | 2.1 | 2.3 | 3 |
| 271 | Dan Fouts | 1985* | 34 | SDG | QB | 14 | 12 | 11 | -1 | 0 | 7 | -0.1 | -0.1 | 13 |
| 272 | Jesse Freitas | 1975 | 24 | SDG | 8 | 4 | 11 | 56 | 0 | 17 | 5.1 | 7.0 | 3 | |
| 273 | Earnest Jackson | 1983 | 24 | SDG | 12 | 0 | 11 | 39 | 0 | 6 | 3.5 | 3.3 | 1 | |
| 274 | Barry Redden | 1987 | 27 | SDG | 12 | 0 | 11 | 36 | 0 | 7 | 3.3 | 3.0 | 0 | |
| 275 | Billy Volek | 2007 | 31 | SDG | 5 | 0 | 11 | -7 | 0 | 0 | -0.6 | -1.4 | 1 | |
| 276 | Jim Allison | 1967 | 24 | SDG | 3 | 0 | 10 | 34 | 0 | 26 | 3.4 | 11.3 | 0 | |
| 277 | Hank Bauer | 1980 | 26 | SDG | 16 | 0 | 10 | 34 | 1 | 7 | 3.4 | 2.1 | 0 | |
| 278 | Bobby Douglass | 1975 | 28 | SDG | 3 | 0 | 10 | 42 | 0 | 9 | 4.2 | 14.0 | 1 | |
| 279 | John Friesz | 1993 | 26 | SDG | qb | 12 | 6 | 10 | 3 | 0 | 2 | 0.3 | 0.3 | 2 |
| 280 | John Friesz | 1991 | 24 | SDG | QB | 16 | 16 | 10 | 18 | 0 | 11 | 1.8 | 1.1 | 10 |
| 281 | James Harris | 1977 | 30 | SDG | QB | 9 | 9 | 10 | 13 | 2 | 12 | 1.3 | 1.4 | 4 |
| 282 | James Harris | 1978 | 31 | SDG | 9 | 2 | 10 | 7 | 0 | 9 | 0.7 | 0.8 | 5 | |
| 283 | Tobin Rote | 1964 | 36 | SDG | qb | 14 | 5 | 10 | -12 | 0 | 9 | -1.2 | -0.9 | 6 |
| 284 | Oscar Dragon | 1972 | 22 | SDG | 13 | 0 | 9 | 30 | 0 | 7 | 3.3 | 2.3 | 0 | |
| 285 | Tim Dwight | 2003 | 28 | SDG | 9 | 3 | 9 | 88 | 0 | 20 | 9.8 | 9.8 | 1 | |
| 286 | Dan Fouts | 1982*+ | 31 | SDG | QB | 9 | 9 | 9 | 8 | 1 | 9 | 0.9 | 0.9 | 2 |
| 287 | Ed Luther | 1983 | 26 | SDG | qb | 16 | 6 | 9 | -14 | 0 | 8 | -1.6 | -0.9 | 6 |
| 288 | Erric Pegram | 1997 | 28 | SDG | 4 | 0 | 9 | 23 | 1 | 18 | 2.6 | 5.8 | 0 | |
| 289 | Andrew Pinnock | 2004 | 24 | SDG | 1 | 0 | 9 | 26 | 0 | 11 | 2.9 | 26.0 | 1 | |
| 290 | Ron Waller | 1960 | 27 | LAC | 2 | 0 | 9 | 5 | 0 | 3 | 0.6 | 2.5 | 2 | |
| 291 | Jesse Chatman | 2003 | 24 | SDG | 16 | 0 | 8 | 17 | 0 | 6 | 2.1 | 1.1 | 0 | |
| 292 | Rodney Culver | 1994 | 25 | SDG | 3 | 0 | 8 | 63 | 0 | 22 | 7.9 | 21.0 | 0 | |
| 293 | Victor Floyd | 1989 | 23 | SDG | 6 | 0 | 8 | 15 | 0 | 5 | 1.9 | 2.5 | 1 | |
| 294 | Gale Gilbert | 1994 | 33 | SDG | 15 | 1 | 8 | -3 | 0 | 5 | -0.4 | -0.2 | 0 | |
| 295 | John Hadl | 1963 | 23 | SDG | 14 | 0 | 8 | 26 | 0 | 33 | 3.3 | 1.9 | 0 | |
| 296 | Stan Humphries | 1993 | 28 | SDG | QB | 12 | 10 | 8 | 37 | 0 | 27 | 4.6 | 3.1 | 2 |
| 297 | Ronney Jenkins | 2000 | 23 | SDG | RET | 16 | 0 | 8 | 6 | 0 | 4 | 0.8 | 0.4 | 3 |
| 298 | Jack Kemp | 1962* | 27 | SDG | 2 | 2 | 8 | 28 | 1 | 19 | 3.5 | 14.0 | 2 | |
| 299 | Booker Russell | 1980 | 24 | SDG | 15 | 0 | 8 | 41 | 0 | 10 | 5.1 | 2.7 | 1 | |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 300 | Darren Sproles | 2005 | 22 | SDG | RET | 15 | 0 | 8 | 50 | 0 | 21 | 6.3 | 3.3 | 3 |
| 301 | Kenny Bynum | 2000 | 26 | SDG | 14 | 0 | 7 | 26 | 0 | 9 | 3.7 | 1.9 | 0 | |
| 302 | Curtis Conway | 2002 | 31 | SDG | WR | 13 | 13 | 7 | 53 | 2 | 22 | 7.6 | 4.1 | 2 |
| 303 | Curtis Conway | 2001 | 30 | SDG | WR | 16 | 16 | 7 | 116 | 1 | 67 | 16.6 | 7.3 | 1 |
| 304 | Quinn Early | 1988 | 23 | SDG | WR | 16 | 11 | 7 | 63 | 0 | 37 | 9.0 | 3.9 | 1 |
| 305 | Dan Fouts | 1973 | 22 | SDG | QB | 10 | 6 | 7 | 32 | 0 | 16 | 4.6 | 3.2 | 2 |
| 306 | Carwell Gardner | 1997 | 31 | SDG | 5 | 2 | 7 | 20 | 0 | 5 | 2.9 | 4.0 | 0 | |
| 307 | Jacob Hester | 2009 | 24 | SDG | 8 | 7 | 15 | 0 | 7 | 2.1 | 1.9 | 0 | ||
| 308 | Fred McCrary | 2000 | 28 | SDG | FB | 15 | 12 | 7 | 8 | 0 | 4 | 1.1 | 0.5 | 1 |
| 309 | Anthony Miller | 1988 | 23 | SDG | WR | 16 | 15 | 7 | 45 | 0 | 20 | 6.4 | 2.8 | 1 |
| 310 | Cliff Olander | 1977 | 22 | SDG | 2 | 1 | 7 | 30 | 0 | 17 | 4.3 | 15.0 | 0 | |
| 311 | Billy Joe Tolliver | 1989 | 23 | SDG | qb | 5 | 5 | 7 | 0 | 0 | 3 | 0.0 | 0.0 | 4 |
| 312 | Jesse Chatman | 2002 | 23 | SDG | 10 | 0 | 6 | 19 | 0 | 11 | 3.2 | 1.9 | 0 | |
| 313 | Tom Flick | 1986 | 28 | SDG | 11 | 3 | 6 | 5 | 1 | 7 | 0.8 | 0.5 | 1 | |
| 314 | Dan Fouts | 1977 | 26 | SDG | 4 | 4 | 6 | 13 | 0 | 11 | 2.2 | 3.3 | 4 | |
| 315 | Jesse Freitas | 1974 | 23 | SDG | 5 | 3 | 6 | 16 | 0 | 9 | 2.7 | 3.2 | 0 | |
| 316 | Gale Gilbert | 1995 | 34 | SDG | 16 | 1 | 6 | 11 | 0 | 8 | 1.8 | 0.7 | 2 | |
| 317 | James Harris | 1979 | 32 | SDG | 8 | 0 | 6 | 26 | 0 | 18 | 4.3 | 3.3 | 1 | |
| 318 | Jamie Holland | 1989 | 25 | SDG | WR | 16 | 6 | 6 | 46 | 0 | 24 | 7.7 | 2.9 | 0 |
| 319 | Ron Holliday | 1973 | 25 | SDG | WR | 11 | 6 | 6 | 70 | 0 | 22 | 11.7 | 6.4 | 1 |
| 320 | Blanche Martin | 1960 | 23 | LAC | 9 | 0 | 6 | 23 | 0 | 10 | 3.8 | 2.6 | 1 | |
| 321 | Rick Neuheisel | 1987 | 26 | SDG | 3 | 2 | 6 | 41 | 1 | 18 | 6.8 | 13.7 | 1 | |
| 322 | Sean Salisbury | 1996 | 33 | SDG | qb | 16 | 3 | 6 | 14 | 0 | 11 | 2.3 | 0.9 | 3 |
| 323 | Anthony Steels | 1985 | 26 | SDG | 6 | 0 | 6 | 12 | 0 | 3 | 2.0 | 2.0 | 0 | |
| 324 | Tom Thompson | 1974 | 23 | SDG | 12 | 0 | 6 | 8 | 0 | 8 | 1.3 | 0.7 | 0 | |
| 325 | Lance Alworth | 1969* | 29 | SDG | FL | 14 | 0 | 5 | 25 | 0 | 16 | 5.0 | 1.8 | 0 |
| 326 | Reche Caldwell | 2003 | 24 | SDG | 9 | 4 | 5 | 39 | 0 | 14 | 7.8 | 4.3 | 0 | |
| 327 | Wes Chandler | 1981 | 25 | SDG | WR | 12 | 11 | 5 | -1 | 0 | 9 | -0.2 | -0.1 | 1 |
| 328 | Wes Chandler | 1982*+ | 26 | SDG | WR | 8 | 8 | 5 | 32 | 0 | 21 | 6.4 | 4.0 | 0 |
| 329 | Jim Everett | 1997 | 34 | SDG | 4 | 1 | 5 | 6 | 0 | 6 | 1.2 | 1.5 | 2 | |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 330 | Doug Flutie | 2004 | 42 | SDG | 2 | 1 | 5 | 39 | 2 | 20 | 7.8 | 19.5 | 0 | |
| 331 | Willie Frazier | 1970 | 28 | SDG | TE | 14 | 0 | 5 | 120 | 1 | 70 | 24.0 | 8.6 | 1 |
| 332 | Shawn Jefferson | 1993 | 24 | SDG | 16 | 4 | 5 | 53 | 0 | 33 | 10.6 | 3.3 | 0 | |
| 333 | Erik Kramer | 1999 | 35 | SDG | 6 | 4 | 5 | 1 | 0 | 3 | 0.2 | 0.2 | 3 | |
| 334 | Bob Laraba | 1961 | 28 | SDG | rlb | 14 | 0 | 5 | 5 | 1 | 9 | 1.0 | 0.4 | 0 |
| 335 | Moses Moreno | 2000 | 25 | SDG | 6 | 2 | 5 | 20 | 0 | 13 | 4.0 | 3.3 | 3 | |
| 336 | Wayne Morris | 1984 | 30 | SDG | 10 | 3 | 5 | 12 | 1 | 5 | 2.4 | 1.2 | 0 | |
| 337 | Billy Parks | 1971 | 23 | SDG | WR | 10 | 0 | 5 | 77 | 0 | 54 | 15.4 | 7.7 | 2 |
| 338 | Hank Bauer | 1977 | 23 | SDG | 13 | 0 | 4 | 4 | 0 | 3 | 1.0 | 0.3 | 1 | |
| 339 | Reche Caldwell | 2004 | 25 | SDG | wr | 6 | 6 | 4 | 45 | 0 | 20 | 11.3 | 7.5 | 1 |
| 340 | Tim Dwight | 2004 | 29 | SDG | RET | 12 | 0 | 4 | 54 | 0 | 48 | 13.5 | 4.5 | 0 |
| 341 | Dan Fouts | 1986 | 35 | SDG | QB | 12 | 12 | 4 | -3 | 0 | 0 | -0.8 | -0.3 | 4 |
| 342 | Gary Garrison | 1970* | 26 | SDG | WR | 14 | 14 | 4 | 7 | 0 | 10 | 1.8 | 0.5 | 0 |
| 343 | LaRue Harrington | 1980 | 23 | SDG | 4 | 0 | 4 | -7 | 0 | -1 | -1.8 | -1.8 | 0 | |
| 344 | Mark Herrmann | 1987 | 28 | SDG | 3 | 2 | 4 | -1 | 0 | 0 | -0.3 | -0.3 | 1 | |
| 345 | Vincent Jackson | 2008 | 25 | SDG | WR | 16 | 16 | 4 | 69 | 0 | 31 | 17.3 | 4.3 | 1 |
| 346 | Leon Johnson | 2003 | 29 | SDG | RET | 14 | 0 | 4 | 26 | 0 | 18 | 6.5 | 1.9 | 1 |
| 347 | Charlie Jones | 1997 | 25 | SDG | WR | 16 | 11 | 4 | 42 | 0 | 17 | 10.5 | 2.6 | 0 |
| 348 | Charlie Jones | 1998 | 26 | SDG | WR/wr | 16 | 11 | 4 | 39 | 0 | 14 | 9.8 | 2.4 | 1 |
| 349 | Mike Kelley | 1987 | 28 | SDG | 3 | 1 | 4 | 17 | 0 | 10 | 4.3 | 5.7 | 0 | |
| 350 | Jerry LeVias | 1971 | 25 | SDG | RET | 14 | 0 | 4 | 73 | 0 | 38 | 18.3 | 5.2 | 3 |
| 351 | Nate Lewis | 1990 | 24 | SDG | RET | 12 | 3 | 4 | 25 | 1 | 10 | 6.3 | 2.1 | 3 |
| 352 | Clint Longley | 1976 | 24 | SDG | 3 | 1 | 4 | 22 | 0 | 9 | 5.5 | 7.3 | 0 | |
| 353 | Ed Luther | 1984 | 27 | SDG | qb | 15 | 3 | 4 | 11 | 0 | 7 | 2.8 | 0.7 | 2 |
| 354 | Anthony Miller | 1989* | 24 | SDG | WR | 16 | 16 | 4 | 21 | 0 | 24 | 5.3 | 1.3 | 1 |
| 355 | Eric Parker | 2004 | 25 | SDG | WR | 15 | 13 | 4 | 53 | 0 | 38 | 13.3 | 3.5 | 5 |
| 356 | Eric Parker | 2005 | 26 | SDG | WR | 16 | 9 | 4 | 55 | 0 | 30 | 13.8 | 3.4 | 2 |
| 357 | Andrew Pinnock | 2007 | 27 | SDG | 10 | 3 | 4 | 1 | 0 | 5 | 0.3 | 0.1 | 0 | |
| 358 | Andrew Pinnock | 2006 | 26 | SDG | 3 | 0 | 4 | 25 | 0 | 15 | 6.3 | 8.3 | 0 | |
| 359 | Philip Rivers | 2004 | 23 | SDG | 2 | 0 | 4 | -5 | 0 | 0 | -1.3 | -2.5 | 1 | |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 360 | Don Woods | 1980 | 29 | SDG | 2 | 0 | 4 | 10 | 0 | 5 | 2.5 | 5.0 | 0 | |
| 361 | Lance Alworth | 1965*+ | 25 | SDG | FL | 14 | 0 | 3 | -12 | 0 | -1 | -4.0 | -0.9 | 2 |
| 362 | Lance Alworth | 1968*+ | 28 | SDG | FL | 14 | 0 | 3 | 18 | 0 | 10 | 6.0 | 1.3 | 0 |
| 363 | Lance Alworth | 1966*+ | 26 | SDG | FL | 13 | 0 | 3 | 10 | 0 | 4 | 3.3 | 0.8 | 0 |
| 364 | Lance Alworth | 1964*+ | 24 | SDG | FL | 12 | 0 | 3 | 60 | 2 | 35 | 20.0 | 5.0 | 3 |
| 365 | Rickey Anderson | 1978 | 25 | SDG | 16 | 0 | 3 | 11 | 0 | 6 | 3.7 | 0.7 | 0 | |
| 366 | Larry Barnes | 1978 | 24 | SDG | 4 | 0 | 3 | 8 | 0 | 4 | 2.7 | 2.0 | 0 | |
| 367 | Eric Bieniemy | 1991 | 22 | SDG | 15 | 0 | 3 | 17 | 0 | 15 | 5.7 | 1.1 | 0 | |
| 368 | David Boston | 2003 | 25 | SDG | WR | 14 | 14 | 3 | 18 | 0 | 13 | 6.0 | 1.3 | 2 |
| 369 | Bob Clatterbuck | 1960 | 28 | LAC | 2 | 2 | 3 | 11 | 0 | 9 | 3.7 | 5.5 | 1 | |
| 370 | Curtis Conway | 2000 | 29 | SDG | WR | 14 | 14 | 3 | 31 | 0 | 13 | 10.3 | 2.2 | 0 |
| 371 | Pat Curran | 1975 | 30 | SDG | TE | 14 | 14 | 3 | 21 | 0 | 12 | 7.0 | 1.5 | 1 |
| 372 | Craig Davis | 2007 | 22 | SDG | 14 | 1 | 3 | 9 | 0 | 6 | 3.0 | 0.6 | 1 | |
| 373 | Bob Gagliano | 1992 | 34 | SDG | 5 | 1 | 3 | -4 | 0 | 0 | -1.3 | -0.8 | 1 | |
| 374 | Bob Gagliano | 1991 | 33 | SDG | 2 | 0 | 3 | 19 | 0 | 16 | 6.3 | 9.5 | 2 | |
| 375 | Gary Garrison | 1975 | 31 | SDG | WR | 14 | 14 | 3 | 30 | 0 | 20 | 10.0 | 2.1 | 0 |
| 376 | Jamie Holland | 1988 | 24 | SDG | wr | 16 | 6 | 3 | 19 | 0 | 10 | 6.3 | 1.2 | 1 |
| 377 | Vincent Jackson | 2006 | 23 | SDG | wr | 16 | 7 | 3 | 16 | 0 | 8 | 5.3 | 1.0 | 0 |
| 378 | Shawn Jefferson | 1994 | 25 | SDG | WR | 16 | 16 | 3 | 40 | 0 | 22 | 13.3 | 2.5 | 0 |
| 379 | Jim Jodat | 1982 | 28 | SDG | 7 | 0 | 3 | 7 | 0 | 3 | 2.3 | 1.0 | 0 | |
| 380 | John Kidd | 1993 | 32 | SDG | P | 14 | 0 | 3 | -13 | 1 | 2 | -4.3 | -0.9 | 0 |
| 381 | Bob Laraba | 1960 | 27 | LAC | 14 | 0 | 3 | 13 | 0 | 16 | 4.3 | 0.9 | 2 | |
| 382 | Nate Lewis | 1993 | 27 | SDG | WR | 15 | 9 | 3 | 2 | 0 | 7 | 0.7 | 0.1 | 2 |
| 383 | Nate Lewis | 1991 | 25 | SDG | WR | 16 | 9 | 3 | 10 | 0 | 9 | 3.3 | 0.6 | 0 |
| 384 | Ed Luther | 1981 | 24 | SDG | 16 | 0 | 3 | -8 | 0 | -1 | -2.7 | -0.5 | 0 | |
| 385 | Ed Luther | 1980 | 23 | SDG | 5 | 0 | 3 | 5 | 0 | 9 | 1.7 | 1.0 | 0 | |
| 386 | Jacque MacKinnon | 1965 | 27 | SDG | 14 | 0 | 3 | 17 | 0 | 9 | 5.7 | 1.2 | 0 | |
| 387 | Eric Metcalf | 1997*+ | 29 | SDG | RET | 16 | 1 | 3 | -5 | 0 | 2 | -1.7 | -0.3 | 4 |
| 388 | Anthony Miller | 1990* | 25 | SDG | WR | 16 | 16 | 3 | 13 | 0 | 10 | 4.3 | 0.8 | 2 |
| 389 | Darrin Nelson | 1990 | 31 | SDG | 14 | 0 | 3 | 14 | 0 | 5 | 4.7 | 1.0 | 1 | |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 390 | Eric Parker | 2003 | 24 | SDG | 8 | 4 | 3 | 21 | 0 | 13 | 7.0 | 2.6 | 1 | |
| 391 | Rick Partridge | 1980 | 23 | SDG | P | 16 | 0 | 3 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 392 | Johnny Rodgers | 1977 | 26 | SDG | WR | 11 | 7 | 3 | 44 | 0 | 33 | 14.7 | 4.0 | 2 |
| 393 | Mike Tolbert | 2009 | 24 | SDG | 8 | 3 | 11 | 0 | 5 | 3.7 | 1.4 | 1 | ||
| 394 | Billy Volek | 2009 | 33 | SDG | 1 | 3 | -3 | 0 | -1 | -1.0 | -3.0 | 0 | ||
| 395 | Billy Volek | 2006 | 30 | SDG | 1 | 0 | 3 | -3 | 0 | -1 | -1.0 | -3.0 | 0 | |
| 396 | Lance Alworth | 1963*+ | 23 | SDG | FL | 14 | 0 | 2 | 14 | 0 | 21 | 7.0 | 1.0 | 0 |
| 397 | David Archer | 1989 | 27 | SDG | 16 | 0 | 2 | 14 | 0 | 14 | 7.0 | 0.9 | 0 | |
| 398 | Hank Bauer | 1981 | 27 | SDG | 16 | 0 | 2 | 7 | 0 | 4 | 3.5 | 0.4 | 0 | |
| 399 | Ricky Bell | 1982 | 27 | SDG | 4 | 0 | 2 | 6 | 0 | 4 | 3.0 | 1.5 | 0 | |
| 400 | Rod Bernstine | 1988 | 23 | SDG | TE | 14 | 13 | 2 | 7 | 0 | 5 | 3.5 | 0.5 | 0 |
| 401 | Drew Brees | 2001 | 22 | SDG | 1 | 0 | 2 | 18 | 0 | 13 | 9.0 | 18.0 | 2 | |
| 402 | Jon Brittenum | 1968 | 24 | SDG | 14 | 0 | 2 | -4 | 0 | 0 | -2.0 | -0.3 | 0 | |
| 403 | Reche Caldwell | 2002 | 23 | SDG | 16 | 2 | 2 | 9 | 0 | 6 | 4.5 | 0.6 | 3 | |
| 404 | Reche Caldwell | 2005 | 26 | SDG | 16 | 2 | 2 | 10 | 0 | 7 | 5.0 | 0.6 | 2 | |
| 405 | Virgil Carter | 1975 | 30 | SDG | 1 | 1 | 2 | 11 | 0 | 9 | 5.5 | 11.0 | 0 | |
| 406 | Chris Chambers | 2007 | 29 | SDG | wr | 10 | 7 | 2 | 17 | 0 | 9 | 8.5 | 1.7 | 1 |
| 407 | Wes Chandler | 1983* | 27 | SDG | WR | 16 | 14 | 2 | 25 | 0 | 23 | 12.5 | 1.6 | 3 |
| 408 | Wayne Clark | 1972 | 25 | SDG | 13 | 0 | 2 | -8 | 0 | 3 | -4.0 | -0.6 | 2 | |
| 409 | Andre Coleman | 1996 | 24 | SDG | WR | 16 | 10 | 2 | 0 | 0 | 7 | 0.0 | 0.0 | 4 |
| 410 | Harrison Davis | 1974 | 22 | SDG | WR | 12 | 7 | 2 | -7 | 0 | 2 | -3.5 | -0.6 | 1 |
| 411 | Tim Dwight | 2001 | 26 | SDG | RET | 10 | 2 | 2 | 24 | 1 | 16 | 12.0 | 2.4 | 1 |
| 412 | Mike Fuller | 1980 | 27 | SDG | RET | 16 | 4 | 2 | 0 | 0 | 0 | 0.0 | 0.0 | 3 |
| 413 | Gary Garrison | 1972* | 28 | SDG | WR | 14 | 13 | 2 | -6 | 0 | 0 | -3.0 | -0.4 | 0 |
| 414 | Fred Gillett | 1962 | 26 | SDG | 6 | 0 | 2 | 8 | 0 | 5 | 4.0 | 1.3 | 0 | |
| 415 | Mark Herrmann | 1986 | 27 | SDG | 6 | 1 | 2 | 6 | 0 | 6 | 3.0 | 1.0 | 2 | |
| 416 | Mitch Hoopes | 1976 | 23 | SDG | P | 9 | 0 | 2 | 10 | 0 | 10 | 5.0 | 1.1 | 0 |
| 417 | Shawn Jefferson | 1995 | 26 | SDG | WR | 16 | 15 | 2 | 1 | 0 | 11 | 0.5 | 0.1 | 0 |
| 418 | John Kidd | 1992 | 31 | SDG | P | 16 | 0 | 2 | -13 | 0 | 0 | -6.5 | -0.8 | 1 |
| 419 | Jerry LeVias | 1973 | 27 | SDG | WR | 14 | 11 | 2 | 33 | 0 | 22 | 16.5 | 2.4 | 0 |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 420 | Nate Lewis | 1992 | 26 | SDG | WR | 15 | 7 | 2 | 7 | 0 | 4 | 3.5 | 0.5 | 1 |
| 421 | Tony Martin | 1994 | 29 | SDG | 16 | 1 | 2 | -9 | 0 | 4 | -4.5 | -0.6 | 2 | |
| 422 | Keenan McCardell | 2005 | 35 | SDG | WR | 16 | 16 | 2 | 6 | 0 | 3 | 3.0 | 0.4 | 0 |
| 423 | Fred McCrary | 2001 | 29 | SDG | FB | 16 | 12 | 2 | 3 | 0 | 2 | 1.5 | 0.2 | 0 |
| 424 | Fred McCrary | 2002 | 30 | SDG | FB | 16 | 16 | 2 | 1 | 0 | 2 | 0.5 | 0.1 | 1 |
| 425 | Greg McCrary | 1978 | 26 | SDG | 8 | 1 | 2 | 18 | 0 | 16 | 9.0 | 2.3 | 0 | |
| 426 | Legedu Naanee | 2009 | 26 | SDG | 7 | 2 | 5 | 0 | 10 | 2.5 | 0.7 | 0 | ||
| 427 | Eric Parker | 2006 | 27 | SDG | WR | 15 | 12 | 2 | 19 | 0 | 18 | 9.5 | 1.3 | 0 |
| 428 | Gary Plummer | 1990 | 30 | SDG | LILB | 16 | 15 | 2 | 3 | 1 | 2 | 1.5 | 0.2 | 0 |
| 429 | Eddie Ray | 1971 | 24 | SDG | 4 | 0 | 2 | 15 | 0 | 8 | 7.5 | 3.8 | 0 | |
| 430 | Rick Redman | 1966 | 23 | SDG | MLB/llb | 14 | 0 | 2 | 14 | 0 | 32 | 7.0 | 1.0 | 0 |
| 431 | Mikhael Ricks | 1999 | 25 | SDG | WR | 16 | 15 | 2 | 11 | 0 | 7 | 5.5 | 0.7 | 0 |
| 432 | Jerry Robinson | 1962 | 23 | SDG | FL | 14 | 0 | 2 | 10 | 0 | 7 | 5.0 | 0.7 | 1 |
| 433 | Chris Samuels | 1991 | 22 | SDG | 3 | 0 | 2 | 10 | 0 | 6 | 5.0 | 3.3 | 0 | |
| 434 | Kay Stephenson | 1967 | 23 | SDG | 7 | 0 | 2 | 11 | 0 | 7 | 5.5 | 1.6 | 0 | |
| 435 | Mark Vlasic | 1988 | 25 | SDG | 2 | 2 | 2 | 0 | 0 | 0 | 0.0 | 0.0 | 1 | |
| 436 | Charlie Whitehurst | 2006 | 24 | SDG | 2 | 0 | 2 | 13 | 1 | 14 | 6.5 | 6.5 | 0 | |
| 437 | Lance Alworth | 1962 | 22 | SDG | 4 | 0 | 1 | 17 | 0 | 17 | 17.0 | 4.3 | 0 | |
| 438 | Lance Alworth | 1967*+ | 27 | SDG | FL | 11 | 0 | 1 | 5 | 0 | 5 | 5.0 | 0.5 | 0 |
| 439 | Dave Atkins | 1975 | 26 | SDG | 3 | 0 | 1 | 4 | 0 | 4 | 4.0 | 1.3 | 0 | |
| 440 | Darren Bennett | 1999 | 34 | SDG | P | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 441 | Rod Bernstine | 1987 | 22 | SDG | 10 | 2 | 1 | 9 | 0 | 9 | 9.0 | 0.9 | 0 | |
| 442 | Don Breaux | 1965 | 25 | SDG | 14 | 0 | 1 | -1 | 0 | -1 | -1.0 | -0.1 | 2 | |
| 443 | John Cappelletti | 1983 | 31 | SDG | 1 | 0 | 1 | 5 | 0 | 5 | 5.0 | 5.0 | 0 | |
| 444 | Joe Caravello | 1989 | 26 | SDG | TE | 12 | 9 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 445 | Mike Carter | 1972 | 24 | SDG | 5 | 0 | 1 | 25 | 0 | 25 | 25.0 | 5.0 | 0 | |
| 446 | Chris Chambers | 2008 | 30 | SDG | WR | 14 | 9 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 447 | Wes Chandler | 1985* | 29 | SDG | WR | 15 | 13 | 1 | 9 | 0 | 9 | 9.0 | 0.6 | 1 |
| 448 | Pat Curran | 1976 | 31 | SDG | TE | 14 | 14 | 1 | 12 | 0 | 12 | 12.0 | 0.9 | 0 |
| 449 | Pat Curran | 1977 | 32 | SDG | te | 14 | 5 | 1 | 2 | 0 | 2 | 2.0 | 0.1 | 0 |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 450 | Chuck Dicus | 1972 | 24 | SDG | WR | 10 | 0 | 1 | -11 | 0 | -11 | -11.0 | -1.1 | 1 |
| 451 | Chuck Dicus | 1971 | 23 | SDG | 14 | 0 | 1 | -2 | 0 | -2 | -2.0 | -0.1 | 0 | |
| 452 | Marty Domres | 1971 | 24 | SDG | 4 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 | |
| 453 | Larry Dorsey | 1976 | 23 | SDG | 13 | 2 | 1 | -12 | 0 | -12 | -12.0 | -0.9 | 1 | |
| 454 | Quinn Early | 1989 | 24 | SDG | 6 | 3 | 1 | 19 | 0 | 19 | 19.0 | 3.2 | 0 | |
| 455 | Doug Flutie | 2002 | 40 | SDG | 1 | 0 | 1 | 6 | 0 | 6 | 6.0 | 6.0 | 0 | |
| 456 | John Friesz | 1990 | 23 | SDG | 1 | 1 | 1 | 3 | 0 | 3 | 3.0 | 3.0 | 0 | |
| 457 | Mike Fuller | 1977 | 24 | SDG | SS | 14 | 14 | 1 | 7 | 1 | 7 | 7.0 | 0.5 | 2 |
| 458 | Mike Fuller | 1979 | 26 | SDG | SS | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 4 |
| 459 | Gary Garrison | 1971* | 27 | SDG | WR | 14 | 14 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 460 | Gary Garrison | 1967 | 23 | SDG | SE | 14 | 14 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 461 | Gary Garrison | 1966 | 22 | SDG | SE | 14 | 12 | 1 | -3 | 0 | -3 | -3.0 | -0.2 | 0 |
| 462 | Dick Gordon | 1974 | 30 | SDG | RET | 7 | 0 | 1 | 25 | 0 | 25 | 25.0 | 3.6 | 4 |
| 463 | Steve Hendrickson | 1993 | 27 | SDG | LLB | 16 | 10 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 464 | Steve Hendrickson | 1994 | 28 | SDG | 16 | 0 | 1 | 3 | 0 | 3 | 3.0 | 0.2 | 0 | |
| 465 | Steve Hendrickson | 1991 | 25 | SDG | 15 | 4 | 1 | 3 | 1 | 3 | 3.0 | 0.2 | 0 | |
| 466 | Jamie Holland | 1987 | 23 | SDG | 12 | 0 | 1 | 17 | 0 | 17 | 17.0 | 1.4 | 0 | |
| 467 | Vincent Jackson | 2009 | 26 | SDG | 9 | 1 | -4 | 0 | -4 | -4.0 | -0.4 | 0 | ||
| 468 | John Jefferson | 1978* | 22 | SDG | WR | 14 | 14 | 1 | 7 | 0 | 7 | 7.0 | 0.5 | 0 |
| 469 | John Jefferson | 1980*+ | 24 | SDG | WR | 16 | 16 | 1 | 16 | 0 | 16 | 16.0 | 1.0 | 0 |
| 470 | Shawn Jefferson | 1991 | 22 | SDG | 16 | 3 | 1 | 27 | 0 | 27 | 27.0 | 1.7 | 0 | |
| 471 | Neal Jeffrey | 1976 | 23 | SDG | 5 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 | |
| 472 | Ronney Jenkins | 2001 | 24 | SDG | RET | 16 | 0 | 1 | -1 | 0 | -1 | -1.0 | -0.1 | 1 |
| 473 | Charlie Joiner | 1979* | 32 | SDG | WR | 16 | 16 | 1 | -12 | 0 | -12 | -12.0 | -0.8 | 1 |
| 474 | Charlie Jones | 1999 | 27 | SDG | 8 | 1 | 1 | -8 | 0 | -8 | -8.0 | -1.0 | 1 | |
| 475 | Val Keckin | 1962 | 24 | SDG | 6 | 0 | 1 | 3 | 0 | 3 | 3.0 | 0.5 | 2 | |
| 476 | Paul Lowe | 1968 | 32 | SDG | 1 | 0 | 1 | 9 | 0 | 9 | 9.0 | 9.0 | 0 | |
| 477 | Ed Luther | 1982 | 25 | SDG | 9 | 0 | 1 | -13 | 0 | -13 | -13.0 | -1.4 | 1 | |
| 478 | Paul Maguire | 1961 | 23 | SDG | RLB | 14 | 0 | 1 | -11 | 0 | -11 | -11.0 | -0.8 | 0 |
| 479 | Brandon Manumaleuna | 2006 | 26 | SDG | te | 16 | 7 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 480 | Bruce Mathison | 1983 | 24 | SDG | 1 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 | |
| 481 | Bruce Mathison | 1986 | 27 | SDG | 2 | 0 | 1 | -1 | 0 | -1 | -1.0 | -0.5 | 0 | |
| 482 | Keenan McCardell | 2006 | 36 | SDG | WR | 14 | 11 | 1 | 8 | 0 | 8 | 8.0 | 0.6 | 2 |
| 483 | Keenan McCardell | 2004 | 34 | SDG | wr | 7 | 6 | 1 | 3 | 0 | 3 | 3.0 | 0.4 | 0 |
| 484 | Anthony Miller | 1992* | 27 | SDG | WR | 16 | 16 | 1 | -1 | 0 | -1 | -1.0 | -0.1 | 0 |
| 485 | Anthony Miller | 1993* | 28 | SDG | WR | 16 | 16 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 486 | Tim Moffett | 1987 | 25 | SDG | 3 | 1 | 1 | 1 | 0 | 1 | 1.0 | 0.3 | 0 | |
| 487 | Ralf Mojsiejenko | 1985 | 22 | SDG | P | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 488 | Bill Munson | 1977 | 36 | SDG | 4 | 0 | 1 | 2 | 0 | 2 | 2.0 | 0.5 | 2 | |
| 489 | Pettis Norman | 1973 | 34 | SDG | TE | 14 | 12 | 1 | 10 | 0 | 10 | 10.0 | 0.7 | 0 |
| 490 | Pettis Norman | 1971 | 32 | SDG | TE | 14 | 0 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 491 | Pettis Norman | 1972 | 33 | SDG | TE | 13 | 0 | 1 | 9 | 0 | 9 | 9.0 | 0.7 | 2 |
| 492 | Don Norton | 1965 | 27 | SDG | SE | 14 | 0 | 1 | -5 | 0 | -5 | -5.0 | -0.4 | 2 |
| 493 | Don Norton | 1960 | 22 | LAC | 14 | 0 | 1 | 2 | 0 | 2 | 2.0 | 0.1 | 1 | |
| 494 | Cliff Olander | 1978 | 23 | SDG | 9 | 0 | 1 | -3 | 0 | -3 | -3.0 | -0.3 | 0 | |
| 495 | Kassim Osgood | 2005 | 25 | SDG | 12 | 3 | 1 | 4 | 0 | 4 | 4.0 | 0.3 | 0 | |
| 496 | Artie Owens | 1977 | 24 | SDG | 14 | 1 | 1 | 3 | 0 | 3 | 3.0 | 0.2 | 2 | |
| 497 | Dennis Partee | 1971 | 25 | SDG | P | 14 | 0 | 1 | 7 | 0 | 7 | 7.0 | 0.5 | 0 |
| 498 | Todd Philcox | 1997 | 31 | SDG | 2 | 0 | 1 | 3 | 0 | 3 | 3.0 | 1.5 | 2 | |
| 499 | Andrew Pinnock | 2005 | 25 | SDG | 11 | 0 | 1 | 4 | 0 | 4 | 4.0 | 0.4 | 0 | |
| 500 | Gary Plummer | 1989 | 29 | SDG | LILB | 16 | 16 | 1 | 6 | 0 | 6 | 6.0 | 0.4 | 0 |
| 501 | Rick Redman | 1967* | 24 | SDG | MLB | 14 | 0 | 1 | -13 | 0 | -13 | -13.0 | -0.9 | 1 |
| 502 | Philip Rivers | 2005 | 24 | SDG | 2 | 0 | 1 | -1 | 0 | -1 | -1.0 | -0.5 | 2 | |
| 503 | George Roberts | 1981 | 26 | SDG | P | 16 | 0 | 1 | 2 | 0 | 2 | 2.0 | 0.1 | 0 |
| 504 | Jerry Robinson | 1964 | 25 | SDG | 14 | 0 | 1 | 10 | 0 | 10 | 10.0 | 0.7 | 3 | |
| 505 | Johnny Rodgers | 1978 | 27 | SDG | 6 | 0 | 1 | 5 | 0 | 5 | 5.0 | 0.8 | 1 | |
| 506 | Mike Scifres | 2006 | 26 | SDG | P | 16 | 0 | 1 | -7 | 0 | -7 | -7.0 | -0.4 | 1 |
| 507 | Bobby Shaw | 2004 | 29 | SDG | 7 | 0 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 | |
| 508 | Pat Shea | 1965 | 26 | SDG | 8 | 0 | 1 | -5 | 0 | -5 | -5.0 | -0.6 | 0 | |
| 509 | Eric Sievers | 1983 | 26 | SDG | TE | 16 | 9 | 1 | -7 | 0 | -7 | -7.0 | -0.4 | 0 |
| Rushing | ||||||||||||||
| Rk | Year | Age | Tm | Pos | G | GS | Att | Yds | TD | Lng | Fmb | |||
| 510 | Anthony Steels | 1987 | 28 | SDG | 2 | 0 | 1 | 3 | 0 | 3 | 3.0 | 1.5 | 0 | |
| 511 | Steve Tensi | 1966 | 24 | SDG | 14 | 1 | 1 | -1 | 0 | -1 | -1.0 | -0.1 | 1 | |
| 512 | Mark Vlasic | 1990 | 27 | SDG | 6 | 1 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 | |
| 513 | Wayne Walker | 1989 | 23 | SDG | 13 | 4 | 1 | 9 | 0 | 9 | 9.0 | 0.7 | 2 | |
| 514 | Jeff West | 1978 | 25 | SDG | P | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 515 | Jeff West | 1979 | 26 | SDG | P | 16 | 0 | 1 | -2 | 0 | -2 | -2.0 | -0.1 | 0 |
| 516 | Jeff West | 1976 | 23 | SDG | 6 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 | |
| 517 | Al Williams | 1987 | 26 | SDG | 3 | 3 | 1 | 11 | 0 | 11 | 11.0 | 3.7 | 1 | |
| 518 | Dave L. Williams | 1972 | 27 | SDG | 12 | 0 | 1 | 14 | 0 | 14 | 14.0 | 1.2 | 0 | |
| 519 | Walter Wilson | 1990 | 24 | SDG | te | 14 | 5 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 520 | Dick Wood | 1962 | 26 | SDG | 6 | 2 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 2 | |
| 521 | Ken Zachary | 1987 | 24 | SDG | 3 | 0 | 1 | 3 | 0 | 3 | 3.0 | 1.0 | 1 | |