| Offensive Starters | | | | | |
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| QB | Baker Mayfield | 24 | 1 | 16 | 317 for 534, 3,827 yards, 22 td, 21 int, & 28 rushes for 141 yards and 3 td | Cleveland Browns / 1st / 1st pick / 2018 |
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| RB | Nick Chubb* | 24 | 1 | 16 | 298 rushes for 1,494 yards, 8 td, & 36 catches for 278 yards and 0 td | Cleveland Browns / 2nd / 35th pick / 2018 |
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| WR | Odell Beckham | 27 | 5 | 15 | 74 catches for 1,035 yards, 4 td, & 3 rushes for 10 yards and 0 td | New York Giants / 1st / 12th pick / 2014 |
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| WR | Jarvis Landry* | 27 | 5 | 16 | 83 catches for 1,174 yards, 6 td, & 1 rush for 10 yards and 0 td | Miami Dolphins / 2nd / 63rd pick / 2014 |
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| T | Chris Hubbard | 28 | 6 | 13 | | |
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| T | Greg Robinson | 27 | 5 | 14 | | St. Louis Rams / 1st / 2nd pick / 2014 |
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| G | Joel Bitonio* | 28 | 5 | 16 | | Cleveland Browns / 2nd / 35th pick / 2014 |
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| G | Wyatt Teller | 25 | 1 | 9 | | Buffalo Bills / 5th / 166th pick / 2018 |
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| C | J.C. Tretter | 28 | 6 | 16 | | Green Bay Packers / 4th / 122nd pick / 2013 |
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| Defensive Starters | | | | | |
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| DE | Myles Garrett | 24 | 2 | 10 | | Cleveland Browns / 1st / 1st pick / 2017 |
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| DE | Chad Thomas | 24 | 1 | 8 | | Cleveland Browns / 3rd / 67th pick / 2018 |
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| DE | Olivier Vernon | 29 | 7 | 10 | | Miami Dolphins / 3rd / 72nd pick / 2012 |
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| DT | Larry Ogunjobi | 25 | 2 | 15 | | Cleveland Browns / 3rd / 65th pick / 2017 |
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| DT | Sheldon Richardson | 29 | 6 | 15 | | New York Jets / 1st / 13th pick / 2013 |
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| LB | Joe Schobert | 26 | 3 | 16 | | Cleveland Browns / 4th / 99th pick / 2016 |
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| LB | Mack Wilson | 21 | Rook | 14 | | Cleveland Browns / 5th / 155th pick / 2019 |
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| CB | Denzel Ward | 22 | 1 | 12 | 0.0 sacks, 2 interceptions, 1 fumble recovered | Cleveland Browns / 1st / 4th pick / 2018 |
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| CB | Greedy Williams | 22 | Rook | 12 | | Cleveland Browns / 2nd / 46th pick / 2019 |
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| S | Damarious Randall | 27 | 4 | 11 | 2.5 sacks, 0 interceptions, 0 fumbles recovered | Green Bay Packers / 1st / 30th pick / 2015 |
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| S | Jermaine Whitehead | 26 | 3 | 8 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| DB | Juston Burris | 26 | 3 | 9 | | New York Jets / 4th / 118th pick / 2016 |
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| Special Teams Starters | | | | | |
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| K | Austin Seibert | 23 | Rook | 0 | 25 of 29 field goals & 30 of 35 extra points | Cleveland Browns / 5th / 170th pick / 2019 |
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| P | Jamie Gillan | 22 | Rook | 0 | 63 punts for a 46.2 average, 1 blocked | |
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