| Offensive Starters | | | | | |
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| QB | Kurt Warner* | 37 | 10 | 16 | 401 for 598, 4,583 yards, 30 td, 14 int, & 18 rushes for -2 yards and 0 td | |
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| RB | Edgerrin James | 30 | 9 | 7 | 133 rushes for 514 yards, 3 td, & 12 catches for 85 yards and 0 td | |
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| WR | Anquan Boldin* | 28 | 5 | 11 | 89 catches for 1,038 yards, 11 td, & 9 rushes for 67 yards and 0 td | |
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| WR | Steve Breaston | 25 | 1 | 9 | 77 catches for 1,006 yards, 3 td, & 2 rushes for 8 yards and 0 td | |
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| WR | Larry Fitzgerald*+ | 25 | 4 | 16 | 96 catches for 1,431 yards, 12 td | |
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| TE | Leonard Pope | 25 | 2 | 8 | 9 catches for 77 yards, 0 td | |
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| LT | Mike Gandy | 29 | 6 | 16 | | |
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| LG | Reggie Wells | 28 | 5 | 16 | | |
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| C | Lyle Sendlein | 24 | 1 | 16 | | |
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| RG | Deuce Lutui | 25 | 2 | 16 | | |
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| RT | Levi Brown | 24 | 1 | 16 | 2 fumbles recovered | |
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| Defensive Starters | | | | | |
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| LDE | Antonio Smith | 27 | 4 | 10 | 3.5 sacks, 0 interceptions, 3 fumbles recovered | |
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| LDT | Bryan Robinson | 34 | 11 | 15 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDT | Darnell Dockett | 27 | 4 | 16 | 4.0 sacks, 0 interceptions, 3 fumbles recovered | |
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| RDE | Travis LaBoy | 27 | 4 | 12 | 4.0 sacks, 0 interceptions, 1 fumble recovered | |
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| LLB | Chike Okeafor | 32 | 9 | 16 | 4.5 sacks, 1 interception, 0 fumbles recovered | |
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| MLB | Gerald Hayes | 28 | 5 | 14 | 0.5 sacks, 0 interceptions, 2 fumbles recovered | |
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| RLB | Karlos Dansby | 27 | 4 | 16 | 4.0 sacks, 2 interceptions, 3 fumbles recovered | |
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| LCB | Roderick Hood | 27 | 5 | 14 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| RCB | Dominique Rodgers-Cromartie | 22 | Rook | 11 | 0.0 sacks, 4 interceptions, 1 fumble recovered | |
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| SS | Adrian Wilson* | 29 | 7 | 14 | 2.5 sacks, 2 interceptions, 0 fumbles recovered | |
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| FS | Antrel Rolle | 26 | 3 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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Roster