| Offensive Starters | | | | | |
| QB | Kurt Warner | 38 | 11 | 15 | 339 for 513, 3,753 yards, 26 td, 14 int, & 21 rushes for 10 yards and 0 td | |
| RB | Tim Hightower | 23 | 1 | 16 | 143 rushes for 598 yards, 8 td, & 63 catches for 428 yards and 0 td | |
| WR | Anquan Boldin | 29 | 6 | 15 | 84 catches for 1,024 yards, 4 td, & 3 rushes for 12 yards and 1 td | |
| WR | Larry Fitzgerald* | 26 | 5 | 16 | 97 catches for 1,092 yards, 13 td | |
| TE | Anthony Becht | 32 | 9 | 10 | 7 catches for 61 yards, 1 td | |
| TE | Ben Patrick | 25 | 2 | 7 | 12 catches for 146 yards, 2 td | |
| LT | Mike Gandy | 30 | 7 | 12 | 2 fumbles recovered | |
| LG | Reggie Wells | 29 | 6 | 16 | | |
| C | Lyle Sendlein | 25 | 2 | 16 | | |
| RG | Deuce Lutui | 26 | 3 | 16 | | |
| RT | Levi Brown | 25 | 2 | 16 | | |
| Defensive Starters | | | | | |
| LDE | Calais Campbell | 23 | 1 | 15 | 7.0 sacks, 0 interceptions, 0 fumbles recovered | |
| NT | Bryan Robinson | 35 | 12 | 15 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDE | Darnell Dockett* | 28 | 5 | 16 | 7.0 sacks, 1 interception, 1 fumble recovered | |
| LOLB | Chike Okeafor | 33 | 10 | 13 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LILB | Karlos Dansby | 28 | 5 | 16 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
| RILB | Gerald Hayes | 29 | 6 | 13 | | |
| ROLB | Clark Haggans | 32 | 9 | 14 | 5.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Bryant McFadden | 28 | 4 | 16 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| RCB | Dominique Rodgers-Cromartie* | 23 | 1 | 16 | 0.0 sacks, 6 interceptions, 0 fumbles recovered | |
| SS | Adrian Wilson*+ | 30 | 8 | 16 | 2.0 sacks, 5 interceptions, 2 fumbles recovered | |
| FS | Antrel Rolle* | 27 | 4 | 15 | 1.5 sacks, 4 interceptions, 1 fumble recovered | |
Roster