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- April 27, 2018: Traded 2018 2nd round pick (51st overall subsequently traded, Anthony Miller) and 2018 4th round pick (117th overall subsequently traded, Jordan Whitehead) to Patriots for 2018 2nd round pick (43rd overall, Kerryon Johnson)
- April 28, 2018: Traded 2019 3rd round pick (73rd overall subsequently traded, David Montgomery) to Patriots for 2018 4th round pick (114th overall, Da'Shawn Hand)
- May 3, 2018: Traded Akeem Spence to Dolphins for 2019 7th round pick (229th overall, P.J. Johnson)
- August 23, 2018: Traded a conditional 2020 pick (7th round pick; conveyed if Harold remains on Lions roster for four weeks) to 49ers for Eli Harold
- September 1, 2018: Traded a conditional 2020 pick (7th round pick) to Panthers for Corey Robinson
- October 25, 2018: Traded 2019 5th round pick (142nd overall subsequently traded, Ben Burr-Kirven) to Giants for Damon Harrison
- October 30, 2018: Traded Golden Tate to Eagles for 2019 3rd round pick (88th overall subsequently traded, Cody Barton)