Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Alex Smith* | 29 | 8 | 15 | 308 for 508, 3,313 yards, 23 td, 7 int, & 76 rushes for 431 yards and 1 td | |
| RB | Jamaal Charles*+ | 27 | 5 | 15 | 259 rushes for 1,287 yards, 12 td, & 70 catches for 693 yards and 7 td | |
| RB | Anthony Sherman | 25 | 2 | 8 | 2 rushes for 3 yards, 0 td, & 18 catches for 155 yards and 1 td | |
| WR | Donnie Avery | 29 | 5 | 14 | 40 catches for 596 yards, 2 td, & 2 rushes for 6 yards and 0 td | |
| WR | Dwayne Bowe | 29 | 6 | 15 | 57 catches for 673 yards, 5 td | |
| TE | Anthony Fasano | 29 | 7 | 9 | 23 catches for 200 yards, 3 td | |
| LT | Branden Albert* | 29 | 5 | 12 | ||
| LG | Jeff Allen | 23 | 1 | 14 | ||
| C | Rodney Hudson | 24 | 2 | 15 | ||
| RG | Jon Asamoah | 25 | 3 | 9 | ||
| RT | Eric Fisher | 22 | Rook | 13 | 1 fumble recovered | |
| Defensive Starters | ||||||
| LDE | Tyson Jackson | 27 | 4 | 9 | 4.0 sacks, 0 interceptions, 0 fumbles recovered | |
| NT | Dontari Poe* | 23 | 1 | 15 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Mike DeVito | 29 | 6 | 13 | ||
| LOLB | Justin Houston* | 24 | 2 | 11 | 11.0 sacks, 0 interceptions, 2 fumbles recovered | |
| LILB | Akeem Jordan | 28 | 6 | 10 | ||
| RILB | Derrick Johnson* | 31 | 8 | 15 | 4.5 sacks, 2 interceptions, 2 fumbles recovered | |
| ROLB | Tamba Hali* | 30 | 7 | 15 | 11.0 sacks, 1 interception, 2 fumbles recovered | |
| LCB | Brandon Flowers* | 27 | 5 | 13 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
| RCB | Sean Smith | 26 | 4 | 15 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| SS | Eric Berry*+ | 25 | 3 | 15 | 3.5 sacks, 3 interceptions, 2 fumbles recovered | |
| FS | Kendrick Lewis | 25 | 3 | 15 | 0.0 sacks, 1 interception, 0 fumbles recovered |
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