Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Alex Smith | 30 | 9 | 15 | 303 for 464, 3,265 yards, 18 td, 6 int, & 49 rushes for 254 yards and 1 td | |
| RB | Jamaal Charles* | 28 | 6 | 15 | 206 rushes for 1,033 yards, 9 td, & 40 catches for 291 yards and 5 td | |
| RB | Anthony Sherman | 26 | 3 | 6 | 2 rushes for 8 yards, 0 td, & 10 catches for 71 yards and 1 td | |
| WR | Dwayne Bowe | 30 | 7 | 15 | 60 catches for 754 yards, 0 td | |
| TE | Anthony Fasano | 30 | 8 | 13 | 25 catches for 226 yards, 4 td | |
| TE | Travis Kelce | 25 | 1 | 11 | 67 catches for 862 yards, 5 td | |
| LT | Eric Fisher | 23 | 1 | 16 | ||
| LG | Mike McGlynn | 29 | 6 | 13 | ||
| C | Rodney Hudson | 25 | 3 | 16 | ||
| RG | Zach Fulton | 23 | Rook | 16 | ||
| RT | Ryan Harris | 29 | 7 | 15 | ||
| Defensive Starters | ||||||
| LDE | Jaye Howard | 26 | 2 | 10 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| NT | Dontari Poe* | 24 | 2 | 16 | 6.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Allen Bailey | 25 | 3 | 14 | 5.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LOLB | Justin Houston*+ | 25 | 3 | 16 | 22.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LILB | Josh Mauga | 27 | 4 | 16 | 0.5 sacks, 0 interceptions, 0 fumbles recovered | |
| RILB | James-Michael Johnson | 25 | 2 | 9 | ||
| ROLB | Tamba Hali* | 31 | 8 | 16 | 6.0 sacks, 0 interceptions, 1 fumble recovered | |
| LCB | Phillip Gaines | 23 | Rook | 5 | ||
| RCB | Sean Smith | 27 | 5 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| SS | Ron Parker | 27 | 3 | 15 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
| FS | Husain Abdullah | 29 | 6 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered |
Roster