| Offensive Starters | | | | | |
| QB | Drew Brees* | 30 | 8 | 15 | 363 for 514, 4,388 yards, 34 td, 11 int, & 22 rushes for 33 yards and 2 td | |
| RB | Reggie Bush | 24 | 3 | 8 | 70 rushes for 390 yards, 5 td, & 47 catches for 335 yards and 3 td | |
| WR | Marques Colston | 26 | 3 | 14 | 70 catches for 1,074 yards, 9 td, & 1 rush for 6 yards and 0 td | |
| WR | Devery Henderson | 27 | 5 | 11 | 51 catches for 804 yards, 2 td, & 4 rushes for 13 yards and 0 td | |
| TE | Jeremy Shockey | 29 | 7 | 12 | 48 catches for 569 yards, 3 td | |
| TE | David Thomas | 26 | 3 | 8 | 35 catches for 356 yards, 1 td | |
| LT | Jermon Bushrod | 25 | 2 | 14 | | |
| LG | Carl Nicks | 24 | 1 | 16 | | |
| C | Jonathan Goodwin* | 31 | 7 | 16 | 1 fumble recovered | |
| RG | Jahri Evans*+ | 26 | 3 | 16 | | |
| RT | Jon Stinchcomb* | 30 | 6 | 16 | | |
| Defensive Starters | | | | | |
| LDE | Charles Grant | 31 | 7 | 16 | 5.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LDT | Remi Ayodele | 26 | 2 | 13 | 1.5 sacks, 0 interceptions, 1 fumble recovered | |
| RDT | Sedrick Ellis | 24 | 1 | 10 | 2.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDE | Will Smith | 28 | 5 | 16 | 13.0 sacks, 1 interception, 0 fumbles recovered | |
| LLB | Scott Fujita | 30 | 7 | 10 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| MLB | Jonathan Vilma* | 27 | 5 | 15 | 2.0 sacks, 3 interceptions, 0 fumbles recovered | |
| RLB | Scott Shanle | 30 | 6 | 14 | 0.0 sacks, 2 interceptions, 2 fumbles recovered | |
| LCB | Jabari Greer | 27 | 5 | 8 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| RCB | Tracy Porter | 23 | 1 | 11 | 0.0 sacks, 4 interceptions, 0 fumbles recovered | |
| SS | Roman Harper* | 27 | 3 | 16 | 1.5 sacks, 0 interceptions, 0 fumbles recovered | |
| FS | Darren Sharper*+ | 34 | 12 | 14 | 0.5 sacks, 9 interceptions, 0 fumbles recovered | |
Roster