Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Drew Brees* | 29 | 7 | 16 | 413 for 635, 5,069 yards, 34 td, 17 int, & 22 rushes for -1 yards and 0 td | |
| RB | Reggie Bush | 23 | 2 | 9 | 106 rushes for 404 yards, 2 td, & 52 catches for 440 yards and 4 td | |
| FB | Mike Karney | 27 | 4 | 8 | 8 rushes for 10 yards, 2 td, & 9 catches for 18 yards and 0 td | |
| WR | Devery Henderson | 26 | 4 | 13 | 32 catches for 793 yards, 3 td, & 4 rushes for 33 yards and 0 td | |
| WR | Lance Moore | 25 | 2 | 6 | 79 catches for 928 yards, 10 td | |
| TE | Jeremy Shockey | 28 | 6 | 11 | 50 catches for 483 yards, 0 td | |
| LT | Jammal Brown* | 27 | 3 | 15 | ||
| LG | Carl Nicks | 23 | Rook | 13 | ||
| C | Jonathan Goodwin | 30 | 6 | 13 | ||
| RG | Jahri Evans | 25 | 2 | 16 | ||
| RT | Jon Stinchcomb | 29 | 5 | 16 | ||
| Defensive Starters | ||||||
| LDE | Charles Grant | 30 | 6 | 8 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LDT | Kendrick Clancy | 30 | 8 | 14 | 2.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDT | Sedrick Ellis | 23 | Rook | 13 | 4.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Will Smith | 27 | 4 | 16 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LLB | Scott Fujita | 29 | 6 | 13 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| MLB | Jonathan Vilma | 26 | 4 | 16 | 1.0 sacks, 1 interception, 3 fumbles recovered | |
| RLB | Scott Shanle | 29 | 5 | 16 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Randall Gay | 26 | 4 | 13 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RCB | Jason David | 26 | 4 | 6 | 0.0 sacks, 5 interceptions, 1 fumble recovered | |
| SS | Roman Harper | 26 | 2 | 15 | ||
| FS | Kevin Kaesviharn | 32 | 7 | 11 | 0.0 sacks, 2 interceptions, 0 fumbles recovered |
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