1981 Week 2
| Sep 10, 1981 | ||
| Pittsburgh Steelers | 10 | Final |
| Miami Dolphins | 30 | |
| PassYds | Bradshaw-PIT | 222 |
| RushYds | Nathan-MIA | 77 |
| RecYds | Nathan-MIA | 84 |
| Sep 13, 1981 | ||
| Houston Oilers | 9 | Final |
| Cleveland Browns | 3 | |
| PassYds | Sipe-CLE | 234 |
| RushYds | Campbell-HOU | 42 |
| RecYds | Pruitt-CLE | 65 |
| Sep 13, 1981 | ||
| Atlanta Falcons | 31 | Final |
| Green Bay Packers | 17 | |
| PassYds | Dickey-GNB | 342 |
| RushYds | Andrews-ATL | 87 |
| RecYds | Lofton-GNB | 179 |
| Sep 13, 1981 | ||
| Tampa Bay Buccaneers | 10 | Final |
| Kansas City Chiefs | 19 | |
| PassYds | Williams-TAM | 294 |
| RushYds | Delaney-KAN | 57 |
| RecYds | House-TAM | 87 |
| Sep 13, 1981 | ||
| Los Angeles Rams | 17 | Final |
| New Orleans Saints | 23 | |
| PassYds | Haden-RAM | 201 |
| RushYds | Rogers-NOR | 162 |
| RecYds | Dennard-RAM | 37 |
| Sep 13, 1981 | ||
| New York Giants | 17 | Final |
| Washington Redskins | 7 | |
| PassYds | Theismann-WAS | 318 |
| RushYds | Kotar-NYG | 38 |
| RecYds | Thompson-WAS | 80 |
| Sep 13, 1981 | ||
| Buffalo Bills | 35 | Final |
| Baltimore Colts | 3 | |
| PassYds | Ferguson-BUF | 261 |
| RushYds | Cribbs-BUF | 66 |
| RecYds | Lewis-BUF | 82 |
| Sep 13, 1981 | ||
| St. Louis Cardinals | 17 | Final |
| Dallas Cowboys | 30 | |
| PassYds | Lomax-STL | 295 |
| RushYds | Dorsett-DAL | 129 |
| RecYds | Johnson-DAL | 80 |
| Sep 13, 1981 | ||
| Cincinnati Bengals | 31 | Final |
| New York Jets | 30 | |
| PassYds | Anderson-CIN | 252 |
| RushYds | McNeil-NYJ | 78 |
| RecYds | Curtis-CIN | 108 |
| Sep 13, 1981 | ||
| New England Patriots | 3 | Final |
| Philadelphia Eagles | 13 | |
| PassYds | Jaworski-PHI | 152 |
| RushYds | Montgomery-PHI | 137 |
| RecYds | Carmichael-PHI | 70 |
| Sep 13, 1981 | ||
| Detroit Lions | 23 | Final |
| San Diego Chargers | 28 | |
| PassYds | Fouts-SDG | 316 |
| RushYds | Sims-DET | 98 |
| RecYds | Joiner-SDG | 166 |
| Sep 13, 1981 | ||
| Denver Broncos | 10 | Final |
| Seattle Seahawks | 13 | |
| PassYds | Zorn-SEA | 199 |
| RushYds | Parros-DEN | 69 |
| RecYds | Hughes-SEA | 59 |
| Sep 13, 1981 | ||
| Chicago Bears | 17 | Final |
| San Francisco 49ers | 28 | |
| PassYds | Montana-SFO | 287 |
| RushYds | Payton-CHI | 97 |
| RecYds | Solomon-SFO | 113 |
| Sep 14, 1981 | ||
| Oakland Raiders | 36 | Final |
| Minnesota Vikings | 10 | |
| PassYds | Dils-MIN | 246 |
| RushYds | King-OAK | 79 |
| RecYds | White-MIN | 140 |
1981 Week Summaries