1981 Week 5
| Oct 4, 1981 | ||
| Baltimore Colts | 17 | Final |
| Buffalo Bills | 23 | |
| PassYds | Jones-BAL | 275 |
| RushYds | Cribbs-BUF | 159 |
| RecYds | Dickey-BAL | 80 |
| Oct 4, 1981 | ||
| Dallas Cowboys | 17 | Final |
| St. Louis Cardinals | 20 | |
| PassYds | Hart-STL | 199 |
| RushYds | Dorsett-DAL | 99 |
| RecYds | Johnson-DAL | 101 |
| Oct 4, 1981 | ||
| Chicago Bears | 21 | Final |
| Minnesota Vikings | 24 | |
| PassYds | Evans-CHI | 307 |
| RushYds | Brown-MIN | 97 |
| RecYds | Margerum-CHI | 140 |
| Oct 4, 1981 | ||
| Kansas City Chiefs | 17 | Final |
| New England Patriots | 33 | |
| PassYds | Cavanaugh-NWE | 162 |
| RushYds | Delaney-KAN | 101 |
| RecYds | Morgan-NWE | 118 |
| Oct 4, 1981 | ||
| Green Bay Packers | 27 | Final |
| New York Giants | 14 | |
| PassYds | Simms-NYG | 230 |
| RushYds | Huckleby-GNB | 88 |
| RecYds | Coffman-GNB | 92 |
| Oct 4, 1981 | ||
| San Francisco 49ers | 30 | Final |
| Washington Redskins | 17 | |
| PassYds | Montana-SFO | 193 |
| RushYds | Riggins-WAS | 47 |
| RecYds | Solomon-SFO | 77 |
| Oct 4, 1981 | ||
| Pittsburgh Steelers | 20 | Final |
| New Orleans Saints | 6 | |
| PassYds | Bradshaw-PIT | 276 |
| RushYds | Rogers-NOR | 77 |
| RecYds | Stallworth-PIT | 158 |
| Oct 4, 1981 | ||
| Cincinnati Bengals | 10 | Final |
| Houston Oilers | 17 | |
| PassYds | Anderson-CIN | 290 |
| RushYds | Campbell-HOU | 182 |
| RecYds | Ross-CIN | 96 |
| Oct 4, 1981 | ||
| New York Jets | 28 | Final |
| Miami Dolphins | 28 | OT |
| PassYds | Todd-NYJ | 310 |
| RushYds | McNeil-NYJ | 79 |
| RecYds | Moore-MIA | 210 |
| Oct 4, 1981 | ||
| Denver Broncos | 17 | Final |
| Oakland Raiders | 0 | |
| PassYds | Morton-DEN | 117 |
| RushYds | Parros-DEN | 73 |
| RecYds | Jensen-OAK | 41 |
| Oct 4, 1981 | ||
| Cleveland Browns | 16 | Final |
| Los Angeles Rams | 27 | |
| PassYds | Sipe-CLE | 250 |
| RushYds | Bryant-RAM | 93 |
| RecYds | Dennard-RAM | 90 |
| Oct 4, 1981 | ||
| Seattle Seahawks | 10 | Final |
| San Diego Chargers | 24 | |
| PassYds | Fouts-SDG | 302 |
| RushYds | Cappelletti-SDG | 85 |
| RecYds | Largent-SEA | 118 |
| Oct 4, 1981 | ||
| Detroit Lions | 10 | Final |
| Tampa Bay Buccaneers | 28 | |
| PassYds | Williams-TAM | 168 |
| RushYds | Sims-DET | 75 |
| RecYds | Scott-DET | 97 |
| Oct 5, 1981 | ||
| Atlanta Falcons | 13 | Final |
| Philadelphia Eagles | 16 | |
| PassYds | Bartkowski-ATL | 232 |
| RushYds | Andrews-ATL | 84 |
| RecYds | Jenkins-ATL | 81 |
1981 Week Summaries