1981 Week 1
| Sep 5, 1981 | ||
| Minnesota Vikings | 13 | Final |
| Tampa Bay Buccaneers | 21 | |
| PassYds | Dils-MIN | 361 |
| RushYds | Brown-MIN | 79 |
| RecYds | White-MIN | 92 |
| Sep 6, 1981 | ||
| New Orleans Saints | 0 | Final |
| Atlanta Falcons | 27 | |
| PassYds | Bartkowski-ATL | 154 |
| RushYds | Andrews-ATL | 86 |
| RecYds | Chandler-NOR | 117 |
| Sep 6, 1981 | ||
| Seattle Seahawks | 21 | Final |
| Cincinnati Bengals | 27 | |
| PassYds | Zorn-SEA | 230 |
| RushYds | Johnson-CIN | 84 |
| RecYds | Largent-SEA | 114 |
| Sep 6, 1981 | ||
| Miami Dolphins | 20 | Final |
| St. Louis Cardinals | 7 | |
| PassYds | Woodley-MIA | 178 |
| RushYds | Anderson-STL | 52 |
| RecYds | Cefalo-MIA | 90 |
| Sep 6, 1981 | ||
| San Francisco 49ers | 17 | Final |
| Detroit Lions | 24 | |
| PassYds | Danielson-DET | 196 |
| RushYds | Patton-SFO | 72 |
| RecYds | Solomon-SFO | 94 |
| Sep 6, 1981 | ||
| Baltimore Colts | 29 | Final |
| New England Patriots | 28 | |
| PassYds | Grogan-NWE | 261 |
| RushYds | McMillan-BAL | 146 |
| RecYds | Hasselbeck-NWE | 111 |
| Sep 6, 1981 | ||
| Philadelphia Eagles | 24 | Final |
| New York Giants | 10 | |
| PassYds | Simms-NYG | 241 |
| RushYds | Montgomery-PHI | 84 |
| RecYds | Taylor-NYG | 62 |
| Sep 6, 1981 | ||
| Kansas City Chiefs | 37 | Final |
| Pittsburgh Steelers | 33 | |
| PassYds | Bradshaw-PIT | 319 |
| RushYds | Harris-PIT | 70 |
| RecYds | Stallworth-PIT | 107 |
| Sep 6, 1981 | ||
| Dallas Cowboys | 26 | Final |
| Washington Redskins | 10 | |
| PassYds | Theismann-WAS | 281 |
| RushYds | Dorsett-DAL | 132 |
| RecYds | Washington-WAS | 124 |
| Sep 6, 1981 | ||
| Green Bay Packers | 16 | Final |
| Chicago Bears | 9 | |
| PassYds | Evans-CHI | 185 |
| RushYds | Ellis-GNB | 94 |
| RecYds | Lofton-GNB | 84 |
| Sep 6, 1981 | ||
| New York Jets | 0 | Final |
| Buffalo Bills | 31 | |
| PassYds | Ferguson-BUF | 254 |
| RushYds | Cribbs-BUF | 61 |
| RecYds | Butler-BUF | 123 |
| Sep 6, 1981 | ||
| Oakland Raiders | 7 | Final |
| Denver Broncos | 9 | |
| PassYds | Morton-DEN | 194 |
| RushYds | Preston-DEN | 87 |
| RecYds | Upchurch-DEN | 64 |
| Sep 6, 1981 | ||
| Houston Oilers | 27 | Final |
| Los Angeles Rams | 20 | |
| PassYds | Stabler-HOU | 169 |
| RushYds | Campbell-HOU | 122 |
| RecYds | Tyler-RAM | 90 |
| Sep 7, 1981 | ||
| San Diego Chargers | 44 | Final |
| Cleveland Browns | 14 | |
| PassYds | Sipe-CLE | 375 |
| RushYds | Muncie-SDG | 161 |
| RecYds | Joiner-SDG | 191 |
1981 Week Summaries