1980 Week 1
| Sep 7, 1980 | ||
| Miami Dolphins | 7 | Final |
| Buffalo Bills | 17 | |
| PassYds | Ferguson-BUF | 198 |
| RushYds | Cribbs-BUF | 60 |
| RecYds | Cribbs-BUF | 71 |
| Sep 7, 1980 | ||
| Tampa Bay Buccaneers | 17 | Final |
| Cincinnati Bengals | 12 | |
| PassYds | Williams-TAM | 155 |
| RushYds | Griffin-CIN | 68 |
| RecYds | Giles-TAM | 62 |
| Sep 7, 1980 | ||
| New York Giants | 41 | Final |
| St. Louis Cardinals | 35 | |
| PassYds | Hart-STL | 322 |
| RushYds | Anderson-STL | 85 |
| RecYds | Gray-NYG | 174 |
| Sep 7, 1980 | ||
| Chicago Bears | 6 | Final |
| Green Bay Packers | 12 | OT |
| PassYds | Phipps-CHI | 174 |
| RushYds | Ivery-GNB | 73 |
| RecYds | Lofton-GNB | 77 |
| Sep 7, 1980 | ||
| Atlanta Falcons | 23 | Final |
| Minnesota Vikings | 24 | |
| PassYds | Kramer-MIN | 395 |
| RushYds | Cain-ATL | 123 |
| RecYds | Rashad-MIN | 160 |
| Sep 7, 1980 | ||
| San Francisco 49ers | 26 | Final |
| New Orleans Saints | 23 | |
| PassYds | Manning-NOR | 314 |
| RushYds | Cooper-SFO | 77 |
| RecYds | Hofer-SFO | 114 |
| Sep 7, 1980 | ||
| Cleveland Browns | 17 | Final |
| New England Patriots | 34 | |
| PassYds | Grogan-NWE | 277 |
| RushYds | Ferguson-NWE | 64 |
| RecYds | Morgan-NWE | 102 |
| Sep 7, 1980 | ||
| Houston Oilers | 17 | Final |
| Pittsburgh Steelers | 31 | |
| PassYds | Bradshaw-PIT | 254 |
| RushYds | Campbell-HOU | 57 |
| RecYds | Stallworth-PIT | 125 |
| Sep 7, 1980 | ||
| Oakland Raiders | 27 | Final |
| Kansas City Chiefs | 14 | |
| PassYds | Pastorini-OAK | 317 |
| RushYds | McKnight-KAN | 77 |
| RecYds | Chandler-OAK | 85 |
| Sep 7, 1980 | ||
| Baltimore Colts | 17 | Final |
| New York Jets | 14 | |
| PassYds | Jones-BAL | 257 |
| RushYds | Washington-BAL | 48 |
| RecYds | Washington-BAL | 67 |
| Sep 7, 1980 | ||
| Denver Broncos | 6 | Final |
| Philadelphia Eagles | 27 | |
| PassYds | Jaworski-PHI | 281 |
| RushYds | Montgomery-PHI | 71 |
| RecYds | Carmichael-PHI | 135 |
| Sep 7, 1980 | ||
| Detroit Lions | 41 | Final |
| Los Angeles Rams | 20 | |
| PassYds | Danielson-DET | 173 |
| RushYds | Sims-DET | 153 |
| RecYds | Sims-DET | 64 |
| Sep 7, 1980 | ||
| San Diego Chargers | 34 | Final |
| Seattle Seahawks | 13 | |
| PassYds | Zorn-SEA | 235 |
| RushYds | Cappelletti-SDG | 112 |
| RecYds | Jefferson-SDG | 103 |
| Sep 8, 1980 | ||
| Dallas Cowboys | 17 | Final |
| Washington Redskins | 3 | |
| PassYds | Theismann-WAS | 190 |
| RushYds | Dorsett-DAL | 66 |
| RecYds | Hill-DAL | 69 |
1980 Week Summaries