| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 2003 | W | San Francisco 49ers | Chicago Bears | 49 | 7 | box | |
| 2 | Sun | September 14, 2003 | L | San Francisco 49ers | @ | St. Louis Rams | 24 | 27 | box |
| 3 | Sun | September 21, 2003 | L | San Francisco 49ers | Cleveland Browns | 12 | 13 | box | |
| 4 | Sun | September 28, 2003 | L | San Francisco 49ers | @ | Minnesota Vikings | 7 | 35 | box |
| 5 | Sun | October 5, 2003 | W | San Francisco 49ers | Detroit Lions | 24 | 17 | box | |
| 6 | Sun | October 12, 2003 | L | San Francisco 49ers | @ | Seattle Seahawks | 19 | 20 | box |
| 7 | Sun | October 19, 2003 | W | San Francisco 49ers | Tampa Bay Buccaneers | 24 | 7 | box | |
| 8 | Sun | October 26, 2003 | L | San Francisco 49ers | @ | Arizona Cardinals | 13 | 16 | box |
| 9 | Sun | November 30, 2003 | L | San Francisco 49ers | @ | Baltimore Ravens | 6 | 44 | box |
| 10 | Sun | December 7, 2003 | W | San Francisco 49ers | Arizona Cardinals | 50 | 14 | box | |
| 11 | Sun | December 14, 2003 | L | San Francisco 49ers | @ | Cincinnati Bengals | 38 | 41 | box |
| 12 | Sun | December 21, 2003 | W | San Francisco 49ers | @ | Philadelphia Eagles | 31 | 28 | box |
| 13 | Sat | December 27, 2003 | L | San Francisco 49ers | Seattle Seahawks | 17 | 24 | box |