| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 11, 2005 | L | Seattle Seahawks | @ | Jacksonville Jaguars | 14 | 26 | box |
| 2 | Sun | September 18, 2005 | W | Seattle Seahawks | Atlanta Falcons | 21 | 18 | box | |
| 3 | Sun | September 25, 2005 | W | Seattle Seahawks | Arizona Cardinals | 37 | 12 | box | |
| 4 | Sun | October 2, 2005 | L | Seattle Seahawks | @ | Washington Redskins | 17 | 20 | box |
| 5 | Sun | October 9, 2005 | W | Seattle Seahawks | @ | St. Louis Rams | 37 | 31 | box |
| 6 | Sun | October 16, 2005 | W | Seattle Seahawks | Houston Texans | 42 | 10 | box | |
| 7 | Sun | October 23, 2005 | W | Seattle Seahawks | Dallas Cowboys | 13 | 10 | box | |
| 8 | Sun | November 6, 2005 | W | Seattle Seahawks | @ | Arizona Cardinals | 33 | 19 | box |
| 9 | Sun | November 13, 2005 | W | Seattle Seahawks | St. Louis Rams | 31 | 16 | box | |
| 10 | Sun | November 20, 2005 | W | Seattle Seahawks | @ | San Francisco 49ers | 27 | 25 | box |
| 11 | Sun | November 27, 2005 | W | Seattle Seahawks | New York Giants | 24 | 21 | box | |
| 12 | Mon | December 5, 2005 | W | Seattle Seahawks | @ | Philadelphia Eagles | 42 | 0 | box |
| 13 | Sun | December 11, 2005 | W | Seattle Seahawks | San Francisco 49ers | 41 | 3 | box | |
| 14 | Sun | December 18, 2005 | W | Seattle Seahawks | @ | Tennessee Titans | 28 | 24 | box |
| 15 | Sat | December 24, 2005 | W | Seattle Seahawks | Indianapolis Colts | 28 | 13 | box | |
| 16 | Sun | January 1, 2006 | L | Seattle Seahawks | @ | Green Bay Packers | 17 | 23 | box |
| 17 | Sat | January 14, 2006 | W | Seattle Seahawks | Washington Redskins | 20 | 10 | box | |
| 18 | Sun | January 22, 2006 | W | Seattle Seahawks | Carolina Panthers | 34 | 14 | box | |
| 19 | Sun | February 5, 2006 | L | Seattle Seahawks | N | Pittsburgh Steelers | 10 | 21 | box |