| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 10, 2006 | L | Detroit Lions | Seattle Seahawks | 6 | 9 | box | |
| 2 | Sun | September 17, 2006 | L | Detroit Lions | @ | Chicago Bears | 7 | 34 | box |
| 3 | Sun | September 24, 2006 | L | Detroit Lions | Green Bay Packers | 24 | 31 | box | |
| 4 | Sun | October 1, 2006 | L | Detroit Lions | @ | St. Louis Rams | 34 | 41 | box |
| 5 | Sun | October 8, 2006 | L | Detroit Lions | @ | Minnesota Vikings | 17 | 26 | box |
| 6 | Sun | October 15, 2006 | W | Detroit Lions | Buffalo Bills | 20 | 17 | box | |
| 7 | Sun | October 22, 2006 | L | Detroit Lions | @ | New York Jets | 24 | 31 | box |
| 8 | Sun | November 5, 2006 | W | Detroit Lions | Atlanta Falcons | 30 | 14 | box | |
| 9 | Sun | November 12, 2006 | L | Detroit Lions | San Francisco 49ers | 13 | 19 | box | |
| 10 | Sun | November 19, 2006 | L | Detroit Lions | @ | Arizona Cardinals | 10 | 17 | box |
| 11 | Thu | November 23, 2006 | L | Detroit Lions | Miami Dolphins | 10 | 27 | box | |
| 12 | Sun | December 3, 2006 | L | Detroit Lions | @ | New England Patriots | 21 | 28 | box |
| 13 | Sun | December 10, 2006 | L | Detroit Lions | Minnesota Vikings | 20 | 30 | box | |
| 14 | Sun | December 17, 2006 | L | Detroit Lions | @ | Green Bay Packers | 9 | 17 | box |
| 15 | Sun | December 24, 2006 | L | Detroit Lions | Chicago Bears | 21 | 26 | box | |
| 16 | Sun | December 31, 2006 | W | Detroit Lions | @ | Dallas Cowboys | 39 | 31 | box |