| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 9, 2007 | W | Detroit Lions | @ | Oakland Raiders | 36 | 21 | box |
| 2 | Sun | September 16, 2007 | W | Detroit Lions | Minnesota Vikings | 20 | 17 | box | |
| 3 | Sun | September 23, 2007 | L | Detroit Lions | @ | Philadelphia Eagles | 21 | 56 | box |
| 4 | Sun | September 30, 2007 | W | Detroit Lions | Chicago Bears | 37 | 27 | box | |
| 5 | Sun | October 7, 2007 | L | Detroit Lions | @ | Washington Redskins | 3 | 34 | box |
| 6 | Sun | October 21, 2007 | W | Detroit Lions | Tampa Bay Buccaneers | 23 | 16 | box | |
| 7 | Sun | October 28, 2007 | W | Detroit Lions | @ | Chicago Bears | 16 | 7 | box |
| 8 | Sun | November 4, 2007 | W | Detroit Lions | Denver Broncos | 44 | 7 | box | |
| 9 | Sun | November 11, 2007 | L | Detroit Lions | @ | Arizona Cardinals | 21 | 31 | box |
| 10 | Sun | November 18, 2007 | L | Detroit Lions | New York Giants | 10 | 16 | box | |
| 11 | Thu | November 22, 2007 | L | Detroit Lions | Green Bay Packers | 26 | 37 | box | |
| 12 | Sun | December 2, 2007 | L | Detroit Lions | @ | Minnesota Vikings | 10 | 42 | box |
| 13 | Sun | December 9, 2007 | L | Detroit Lions | Dallas Cowboys | 27 | 28 | box | |
| 14 | Sun | December 16, 2007 | L | Detroit Lions | @ | San Diego Chargers | 14 | 51 | box |
| 15 | Sun | December 23, 2007 | W | Detroit Lions | Kansas City Chiefs | 25 | 20 | box | |
| 16 | Sun | December 30, 2007 | L | Detroit Lions | @ | Green Bay Packers | 13 | 34 | box |