| Offensive Starters | | | | | |
|---|
| QB | Alex Smith | 27 | 6 | 16 | 273 for 445, 3,144 yards, 17 td, 5 int, & 52 rushes for 179 yards and 2 td | |
|---|
| RB | Frank Gore* | 28 | 6 | 15 | 282 rushes for 1,211 yards, 8 td, & 17 catches for 114 yards and 0 td | |
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| FB | Bruce Miller | 24 | Rook | 8 | 4 rushes for 8 yards, 0 td, & 11 catches for 83 yards and 1 td | |
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| WR | Michael Crabtree | 24 | 2 | 14 | 72 catches for 874 yards, 4 td, & 1 rush for 6 yards and 0 td | |
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| WR | Josh Morgan | 26 | 3 | 5 | 15 catches for 220 yards, 1 td | |
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| TE | Vernon Davis | 27 | 5 | 16 | 67 catches for 792 yards, 6 td, & 2 rushes for -5 yards and 0 td | |
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| LT | Joe Staley* | 27 | 4 | 16 | | |
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| LG | Mike Iupati | 24 | 1 | 16 | | |
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| C | Jonathan Goodwin | 33 | 9 | 16 | | |
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| RG | Adam Snyder | 29 | 6 | 13 | | |
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| RT | Anthony Davis | 22 | 1 | 16 | | |
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| Defensive Starters | | | | | |
|---|
| LDE | Ray McDonald | 27 | 4 | 15 | 5.5 sacks, 0 interceptions, 1 fumble recovered | |
|---|
| NT | Isaac Sopoaga | 30 | 6 | 15 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
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| RDE | Justin Smith*+ | 32 | 10 | 16 | 7.5 sacks, 0 interceptions, 1 fumble recovered | |
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| LOLB | Ahmad Brooks | 27 | 5 | 16 | 7.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LILB | NaVorro Bowman+ | 23 | 1 | 16 | 2.0 sacks, 0 interceptions, 3 fumbles recovered | |
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| RILB | Patrick Willis*+ | 26 | 4 | 13 | 2.0 sacks, 1 interception, 2 fumbles recovered | |
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| ROLB | Parys Haralson | 27 | 5 | 16 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LCB | Carlos Rogers* | 30 | 6 | 16 | 0.0 sacks, 6 interceptions, 0 fumbles recovered | |
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| RCB | Tarell Brown | 26 | 4 | 16 | 0.0 sacks, 4 interceptions, 0 fumbles recovered | |
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| SS | Donte Whitner | 26 | 5 | 15 | 0.0 sacks, 2 interceptions, 3 fumbles recovered | |
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| FS | Dashon Goldson* | 27 | 4 | 14 | 0.0 sacks, 6 interceptions, 1 fumble recovered | |
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Roster