| Single-season | Passing | Rushing | Receiving | Returns | Kicking | Scoring | |
| Career | Passing | Rushing | Receiving | Returns | Kicking | Scoring | Defense |
| Rk | From | To | G | QBrec | Cmp | Att | Yds | TD | Int | Lng | Sk | Yds | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | David Carr | 2002 | 2006 | 76 | 22-53-0 | 1243 | 2070 | 60.0 | 13391 | 59 | 2.9 | 65 | 3.1 | 81 | 6.5 | 5.3 | 10.8 | 176.2 | 75.5 | 249 | 1466 | 5.1 | 4.1 | 10.7 |
| 2 | Matt Schaub | 2007 | 2007 | 11 | 4-7-0 | 192 | 289 | 66.4 | 2241 | 9 | 3.1 | 9 | 3.1 | 77 | 7.8 | 6.7 | 11.7 | 203.7 | 87.2 | 16 | 126 | 6.9 | 5.9 | 5.2 |
| 3 | Sage Rosenfels | 2006 | 2007 | 13 | 4-1-0 | 181 | 279 | 64.9 | 1949 | 18 | 6.5 | 13 | 4.7 | 53 | 7.0 | 5.5 | 10.8 | 149.9 | 87.3 | 7 | 53 | 6.6 | 5.2 | 2.4 |
| 4 | Tony Banks | 2003 | 2005 | 15 | 2-1-0 | 76 | 129 | 58.9 | 882 | 6 | 4.7 | 5 | 3.9 | 46 | 6.8 | 5.6 | 11.6 | 58.8 | 79.0 | 13 | 57 | 5.8 | 4.6 | 9.2 |
| 5 | Dave Ragone | 2003 | 2003 | 2 | 0-2-0 | 20 | 40 | 50.0 | 135 | 0 | 0.0 | 1 | 2.5 | 24 | 3.4 | 2.3 | 6.8 | 67.5 | 47.4 | 8 | 39 | 2.0 | 1.1 | 16.7 |
| 6 | Jabar Gaffney | 2002 | 2004 | 48 | 1 | 5 | 20.0 | 39 | 1 | 20.0 | 0 | 0.0 | 39 | 7.8 | 9.8 | 39.0 | 0.8 | 99.2 | 0 | 0 | 7.8 | 9.8 | 0.0 | |
| 7 | James Allen | 2002 | 2002 | 16 | 1 | 2 | 50.0 | 5 | 1 | 50.0 | 0 | 0.0 | 5 | 2.5 | 7.5 | 5.0 | 0.3 | 95.8 | 0 | 0 | 2.5 | 7.5 | 0.0 | |
| 8 | Stacey Mack | 2003 | 2003 | 8 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 1 | 100.0 | 0 | 0.0 | -45.0 | 0.0 | 0.0 | 0 | 0 | 0.0 | -45.0 | 0.0 | ||
| 9 | Domanick Williams | 2005 | 2005 | 11 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.0 | 0.0 | 39.6 | 0 | 0 | 0.0 | 0.0 | 0.0 |