| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 4, 1988 | W | Buffalo Bills | Minnesota Vikings | 13 | 10 | box | |
| 2 | Sun | September 11, 1988 | W | Buffalo Bills | Miami Dolphins | 9 | 6 | box | |
| 3 | Sun | September 18, 1988 | W | Buffalo Bills | @ | New England Patriots | 16 | 14 | box |
| 4 | Sun | September 25, 1988 | W | Buffalo Bills | Pittsburgh Steelers | 36 | 28 | box | |
| 5 | Sun | October 2, 1988 | L | Buffalo Bills | @ | Chicago Bears | 3 | 24 | box |
| 6 | Sun | October 9, 1988 | W | Buffalo Bills | Indianapolis Colts | 34 | 23 | box | |
| 7 | Mon | October 17, 1988 | W | Buffalo Bills | @ | New York Jets | 37 | 14 | box |
| 8 | Sun | October 23, 1988 | W | Buffalo Bills | New England Patriots | 23 | 20 | box | |
| 9 | Sun | October 30, 1988 | W | Buffalo Bills | Green Bay Packers | 28 | 0 | box | |
| 10 | Sun | November 6, 1988 | W | Buffalo Bills | @ | Seattle Seahawks | 13 | 3 | box |
| 11 | Mon | November 14, 1988 | W | Buffalo Bills | @ | Miami Dolphins | 31 | 6 | box |
| 12 | Sun | November 20, 1988 | W | Buffalo Bills | New York Jets | 9 | 6 | box | |
| 13 | Sun | November 27, 1988 | L | Buffalo Bills | @ | Cincinnati Bengals | 21 | 35 | box |
| 14 | Sun | December 4, 1988 | L | Buffalo Bills | @ | Tampa Bay Buccaneers | 5 | 10 | box |
| 15 | Sun | December 11, 1988 | W | Buffalo Bills | Los Angeles Raiders | 37 | 21 | box | |
| 16 | Sun | December 18, 1988 | L | Buffalo Bills | @ | Indianapolis Colts | 14 | 17 | box |
| 17 | Sun | January 1, 1989 | W | Buffalo Bills | Houston Oilers | 17 | 10 | box | |
| 18 | Sun | January 8, 1989 | L | Buffalo Bills | @ | Cincinnati Bengals | 10 | 21 | box |