| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 9, 1990 | W | Buffalo Bills | Indianapolis Colts | 26 | 10 | box | |
| 2 | Sun | September 16, 1990 | L | Buffalo Bills | @ | Miami Dolphins | 7 | 30 | box |
| 3 | Mon | September 24, 1990 | W | Buffalo Bills | @ | New York Jets | 30 | 7 | box |
| 4 | Sun | September 30, 1990 | W | Buffalo Bills | Denver Broncos | 29 | 28 | box | |
| 5 | Sun | October 7, 1990 | W | Buffalo Bills | Los Angeles Raiders | 38 | 24 | box | |
| 6 | Sun | October 21, 1990 | W | Buffalo Bills | New York Jets | 30 | 27 | box | |
| 7 | Sun | October 28, 1990 | W | Buffalo Bills | @ | New England Patriots | 27 | 10 | box |
| 8 | Sun | November 4, 1990 | W | Buffalo Bills | @ | Cleveland Browns | 42 | 0 | box |
| 9 | Sun | November 11, 1990 | W | Buffalo Bills | Phoenix Cardinals | 45 | 14 | box | |
| 10 | Sun | November 18, 1990 | W | Buffalo Bills | New England Patriots | 14 | 0 | box | |
| 11 | Mon | November 26, 1990 | L | Buffalo Bills | @ | Houston Oilers | 24 | 27 | box |
| 12 | Sun | December 2, 1990 | W | Buffalo Bills | Philadelphia Eagles | 30 | 23 | box | |
| 13 | Sun | December 9, 1990 | W | Buffalo Bills | @ | Indianapolis Colts | 31 | 7 | box |
| 14 | Sat | December 15, 1990 | W | Buffalo Bills | @ | New York Giants | 17 | 13 | box |
| 15 | Sat | January 12, 1991 | W | Buffalo Bills | Miami Dolphins | 44 | 34 | box | |
| 16 | Sun | January 20, 1991 | W | Buffalo Bills | Los Angeles Raiders | 51 | 3 | box | |
| 17 | Sun | January 27, 1991 | L | Buffalo Bills | N | New York Giants | 19 | 20 | box |