| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 21, 1975 | W | Buffalo Bills | New York Jets | 42 | 14 | box | |
| 2 | Sun | September 28, 1975 | W | Buffalo Bills | @ | Pittsburgh Steelers | 30 | 21 | box |
| 3 | Sun | October 5, 1975 | W | Buffalo Bills | Denver Broncos | 38 | 14 | box | |
| 4 | Sun | October 12, 1975 | W | Buffalo Bills | @ | Baltimore Colts | 38 | 31 | box |
| 5 | Mon | October 20, 1975 | L | Buffalo Bills | New York Giants | 14 | 17 | box | |
| 6 | Sun | October 26, 1975 | L | Buffalo Bills | Miami Dolphins | 30 | 35 | box | |
| 7 | Sun | November 2, 1975 | W | Buffalo Bills | @ | New York Jets | 24 | 23 | box |
| 8 | Sun | November 9, 1975 | L | Buffalo Bills | Baltimore Colts | 35 | 42 | box | |
| 9 | Mon | November 17, 1975 | L | Buffalo Bills | @ | Cincinnati Bengals | 24 | 33 | box |
| 10 | Sun | November 23, 1975 | W | Buffalo Bills | New England Patriots | 45 | 31 | box | |
| 11 | Thu | November 27, 1975 | W | Buffalo Bills | @ | St. Louis Cardinals | 32 | 14 | box |
| 12 | Sun | December 7, 1975 | L | Buffalo Bills | @ | Miami Dolphins | 21 | 31 | box |
| 13 | Sun | December 14, 1975 | W | Buffalo Bills | @ | New England Patriots | 34 | 14 | box |
| 14 | Sat | December 20, 1975 | L | Buffalo Bills | Minnesota Vikings | 13 | 35 | box |