| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 3, 1978 | L | Buffalo Bills | Pittsburgh Steelers | 17 | 28 | box | |
| 2 | Sun | September 10, 1978 | L | Buffalo Bills | New York Jets | 20 | 21 | box | |
| 3 | Sun | September 17, 1978 | L | Buffalo Bills | @ | Miami Dolphins | 24 | 31 | box |
| 4 | Sun | September 24, 1978 | W | Buffalo Bills | Baltimore Colts | 24 | 17 | box | |
| 5 | Sun | October 1, 1978 | W | Buffalo Bills | Kansas City Chiefs | 28 | 13 | box | |
| 6 | Sun | October 8, 1978 | L | Buffalo Bills | @ | New York Jets | 14 | 45 | box |
| 7 | Sun | October 15, 1978 | L | Buffalo Bills | @ | Houston Oilers | 10 | 17 | box |
| 8 | Sun | October 22, 1978 | W | Buffalo Bills | Cincinnati Bengals | 5 | 0 | box | |
| 9 | Sun | October 29, 1978 | L | Buffalo Bills | @ | Cleveland Browns | 20 | 41 | box |
| 10 | Sun | November 5, 1978 | L | Buffalo Bills | New England Patriots | 10 | 14 | box | |
| 11 | Sun | November 12, 1978 | L | Buffalo Bills | Miami Dolphins | 24 | 25 | box | |
| 12 | Sun | November 19, 1978 | L | Buffalo Bills | @ | Tampa Bay Buccaneers | 10 | 31 | box |
| 13 | Sun | November 26, 1978 | W | Buffalo Bills | New York Giants | 41 | 17 | box | |
| 14 | Sun | December 3, 1978 | L | Buffalo Bills | @ | Kansas City Chiefs | 10 | 14 | box |
| 15 | Sun | December 10, 1978 | L | Buffalo Bills | @ | New England Patriots | 24 | 26 | box |
| 16 | Sun | December 17, 1978 | W | Buffalo Bills | @ | Baltimore Colts | 21 | 14 | box |