| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 6, 1981 | W | Buffalo Bills | New York Jets | 31 | 0 | box | |
| 2 | Sun | September 13, 1981 | W | Buffalo Bills | @ | Baltimore Colts | 35 | 3 | box |
| 3 | Thu | September 17, 1981 | L | Buffalo Bills | Philadelphia Eagles | 14 | 20 | box | |
| 4 | Sun | September 27, 1981 | L | Buffalo Bills | @ | Cincinnati Bengals | 24 | 27 | box |
| 5 | Sun | October 4, 1981 | W | Buffalo Bills | Baltimore Colts | 23 | 17 | box | |
| 6 | Mon | October 12, 1981 | W | Buffalo Bills | Miami Dolphins | 31 | 21 | box | |
| 7 | Sun | October 18, 1981 | L | Buffalo Bills | @ | New York Jets | 14 | 33 | box |
| 8 | Sun | October 25, 1981 | W | Buffalo Bills | Denver Broncos | 9 | 7 | box | |
| 9 | Sun | November 1, 1981 | W | Buffalo Bills | Cleveland Browns | 22 | 13 | box | |
| 10 | Mon | November 9, 1981 | L | Buffalo Bills | @ | Dallas Cowboys | 14 | 27 | box |
| 11 | Sun | November 15, 1981 | L | Buffalo Bills | @ | St. Louis Cardinals | 0 | 24 | box |
| 12 | Sun | November 22, 1981 | W | Buffalo Bills | New England Patriots | 20 | 17 | box | |
| 13 | Sun | November 29, 1981 | W | Buffalo Bills | Washington Redskins | 21 | 14 | box | |
| 14 | Sun | December 6, 1981 | W | Buffalo Bills | @ | San Diego Chargers | 28 | 27 | box |
| 15 | Sun | December 13, 1981 | W | Buffalo Bills | @ | New England Patriots | 19 | 10 | box |
| 16 | Sat | December 19, 1981 | L | Buffalo Bills | @ | Miami Dolphins | 6 | 16 | box |
| 17 | Sun | December 27, 1981 | W | Buffalo Bills | @ | New York Jets | 31 | 27 | box |
| 18 | Sun | January 3, 1982 | L | Buffalo Bills | @ | Cincinnati Bengals | 21 | 28 | box |