| Nov 24, 1921 | ||
| Canton Bulldogs | 14 | Final |
| Akron Pros | 0 | |
| Nov 24, 1921 | ||
| Buffalo All-Americans | 7 | Final |
| Chicago Staleys | 6 | |
| Nov 27, 1921 | ||
| Dayton Triangles | 0 | Final |
| Buffalo All-Americans | 7 | |
| Nov 27, 1921 | ||
| Green Bay Packers | 0 | Final |
| Chicago Staleys | 20 | |
| Nov 27, 1921 | ||
| Cincinnati Celts | 0 | Final |
| Evansville Crimson Giants | 48 | |
| Nov 27, 1921 | ||
| Canton Bulldogs | 15 | Final |
| Washington Senators | 0 | |
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1921 Week Summaries