| Dec 3, 1921 | ||
| Akron Pros | 0 | Final |
| Buffalo All-Americans | 14 | |
| Dec 3, 1921 | ||
| Cleveland Indians | 17 | Final |
| New York Brickley Giants | 0 | |
| Dec 4, 1921 | ||
| Buffalo All-Americans | 7 | Final |
| Chicago Staleys | 10 | |
| Dec 4, 1921 | ||
| Akron Pros | 7 | Final |
| Chicago Cardinals | 0 | |
| Dec 4, 1921 | ||
| Columbus Panhandles | 6 | Final |
| Louisville Brecks | 0 | |
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1921 Week Summaries