| Nov 13, 1921 | ||
| Akron Pros | 0 | Final |
| Buffalo All-Americans | 0 | |
| Nov 13, 1921 | ||
| Rock Island Independents | 0 | Final |
| Chicago Staleys | 3 | |
| Nov 13, 1921 | ||
| Canton Bulldogs | 7 | Final |
| Cleveland Indians | 0 | |
| Nov 13, 1921 | ||
| Detroit Tigers | 0 | Final |
| Dayton Triangles | 27 | |
| Nov 13, 1921 | ||
| Hammond Pros | 7 | Final |
| Green Bay Packers | 14 | |
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Pre-1994 play-by-play courtesy of Aaron Schatz of FTN Fantasy and Jeremy Snyder of Quirky Research.
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1921 Week Summaries