| Oct 2, 1921 | ||
| Cincinnati Celts | 0 | Final |
| Akron Pros | 41 | |
| Oct 2, 1921 | ||
| Hammond Pros | 0 | Final |
| Buffalo All-Americans | 17 | |
| Oct 2, 1921 | ||
| Minneapolis Marines | 0 | Final |
| Chicago Cardinals | 20 | |
| Oct 2, 1921 | ||
| Columbus Panhandles | 13 | Final |
| Dayton Triangles | 42 | |
| Oct 2, 1921 | ||
| Louisville Brecks | 0 | Final |
| Evansville Crimson Giants | 21 | |
| Oct 2, 1921 | ||
| Detroit Tigers | 0 | Final |
| Rock Island Independents | 0 | |
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1921 Week Summaries