| Nov 20, 1921 | ||
| Canton Bulldogs | 7 | Final |
| Buffalo All-Americans | 7 | |
| Nov 20, 1921 | ||
| Cleveland Indians | 7 | Final |
| Chicago Staleys | 22 | |
| Nov 20, 1921 | ||
| Green Bay Packers | 3 | Final |
| Chicago Cardinals | 3 | |
| Nov 20, 1921 | ||
| Akron Pros | 0 | Final |
| Dayton Triangles | 3 | |
| Nov 20, 1921 | ||
| Columbus Panhandles | 13 | Final |
| Rochester Jeffersons | 27 | |
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1921 Week Summaries