1921 Week 5
| Oct 23, 1921 | ||
| Rochester Jeffersons | 0 | Final |
| Buffalo All-Americans | 28 | |
| Oct 23, 1921 | ||
| Akron Pros | 3 | Final |
| Canton Bulldogs | 0 | |
| Oct 23, 1921 | ||
| Dayton Triangles | 0 | Final |
| Chicago Staleys | 7 | |
| Oct 23, 1921 | ||
| Columbus Panhandles | 6 | Final |
| Chicago Cardinals | 17 | |
| Oct 23, 1921 | ||
| Cincinnati Celts | 0 | Final |
| Cleveland Indians | 28 | |
| Oct 23, 1921 | ||
| Rock Island Independents | 14 | Final |
| Detroit Tigers | 0 | |
| Oct 23, 1921 | ||
| Minneapolis Marines | 6 | Final |
| Green Bay Packers | 7 | |

1921 Week Summaries